Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor
about
Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant miceHaploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communicationSynaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis.Discovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the Shank3 PDZ domainGlutamate receptor ion channels: structure, regulation, and functionUsing mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactionsUsing Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autismExcess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disabilitySHANK proteins: roles at the synapse and in autism spectrum disorder.Ultrastructural analyses in the hippocampus CA1 field in Shank3-deficient mice.Phelan-McDermid Syndrome and SHANK3: Implications for Treatment.Structural modeling of protein interactions by analogy: application to PSD-95Loss of predominant Shank3 isoforms results in hippocampus-dependent impairments in behavior and synaptic transmission.A general screening strategy for peptide-based fluorogenic ligands: probes for dynamic studies of PDZ domain-mediated interactions.Analysis of the potential role of GluA4 carboxyl-terminus in PDZ interactionsAutism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits.Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors.Synaptic plasticity in mouse models of autism spectrum disorders.Novel Therapeutic Approach for Autism Spectrum Disorder: Focus on SHANK3Modeling autism by SHANK gene mutations in mice.A blueprint for research on Shankopathies: a view from research on autism spectrum disorder.The Potential Role of Insulin on the Shank-Postsynaptic Platform in Neurodegenerative Diseases Involving Cognition.Synaptic basis of social dysfunction: a focus on postsynaptic proteins linking group-I mGluRs with AMPARs and NMDARs.Identification of two novel Shank3 transcripts in the developing mouse neocortex.Association analysis of genetic variant of rs13331 in PSD95 gene with autism spectrum disorders: A case-control study in a Chinese population.Fundamental Elements in Autism: From Neurogenesis and Neurite Growth to Synaptic Plasticity.Sensitivity to isoflurane anesthesia increases in autism spectrum disorder Shank3+/∆c mutant mouse model.A commonly carried genetic variant, rs9616915, in SHANK3 gene is associated with a reduced risk of autism spectrum disorder: replication in a Chinese population.nArgBP2-SAPAP-SHANK, the core postsynaptic triad associated with psychiatric disorders.
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P2860
Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor
description
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
scientific journal article
@en
vedecký článok (publikovaný 2006/05/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/05/01)
@nl
наукова стаття, опублікована в травні 2006
@uk
مقالة علمية (نشرت في مايو 2006)
@ar
name
Direct interaction of post-syn ...... xazole propionic acid receptor
@ast
Direct interaction of post-syn ...... xazole propionic acid receptor
@en
Direct interaction of post-syn ...... xazole propionic acid receptor
@nl
type
label
Direct interaction of post-syn ...... xazole propionic acid receptor
@ast
Direct interaction of post-syn ...... xazole propionic acid receptor
@en
Direct interaction of post-syn ...... xazole propionic acid receptor
@nl
prefLabel
Direct interaction of post-syn ...... xazole propionic acid receptor
@ast
Direct interaction of post-syn ...... xazole propionic acid receptor
@en
Direct interaction of post-syn ...... xazole propionic acid receptor
@nl
P2093
P2860
P921
P1476
Direct interaction of post-syn ...... xazole propionic acid receptor
@en
P2093
Eri Suzuki
Hidenori Wada
Moe Tsutsumi
Shigeo Uchino
Shinichi Kohsaka
Shizuyo Honda
Takae Hirasawa
Takayoshi Uchiyama
Yasuko Nakamura
Yumiko Ondo
P2860
P304
P356
10.1111/J.1471-4159.2006.03831.X
P407
P577
2006-05-01T00:00:00Z