Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase.
about
New insights into an X-traordinary viral proteinSAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx ProteinIdentification and characterization of naturally occurring splice variants of SAMHD1SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutationsMechanism of allosteric activation of SAMHD1 by dGTPStructural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolaseThe restriction factors of human immunodeficiency virusHow SAMHD1 changes our view of viral restrictionSAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cellsSAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphatesTetramerization of SAMHD1 is required for biological activity and inhibition of HIV infectionRecent Advances in Lentiviral Vaccines for HIV-1 InfectionRegulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implicationsHIV restriction in quiescent CD4⁺ T cellsThe enemy within: endogenous retroelements and autoimmune diseaseMechanisms of Allosteric Activation and Inhibition of the Deoxyribonucleoside Triphosphate Triphosphohydrolase from Enterococcus faecalisHow SLX4 cuts through the mystery of HIV-1 Vpr-mediated cell cycle arrest.The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTPIntrinsic cellular defenses against human immunodeficiency virusesMouse models for Aicardi-Goutières syndrome provide clues to the molecular pathogenesis of systemic autoimmunityIntrinsic antiviral immunityThe ribonuclease activity of SAMHD1 is required for HIV-1 restrictionCo-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in HIV-1 ancestorSAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.Animal models for HIV/AIDS researchdGTP starvation in Escherichia coli provides new insights into the thymineless-death phenomenon.Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated stateNuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to VpxMAC induced ubiquitination and proteasomal degradation.Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory proteinSAMHD1 has differential impact on the efficacies of HIV nucleoside reverse transcriptase inhibitors.Mouse knockout models for HIV-1 restriction factors.dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.Leishmania induces survival, proliferation and elevated cellular dNTP levels in human monocytes promoting acceleration of HIV co-infection.HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction.The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation
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Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase.
description
2011 nî lūn-bûn
@nan
2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Aicardi-Goutieres syndrome gen ...... ucleotide triphosphohydrolase.
@ast
Aicardi-Goutieres syndrome gen ...... ucleotide triphosphohydrolase.
@en
type
label
Aicardi-Goutieres syndrome gen ...... ucleotide triphosphohydrolase.
@ast
Aicardi-Goutieres syndrome gen ...... ucleotide triphosphohydrolase.
@en
prefLabel
Aicardi-Goutieres syndrome gen ...... ucleotide triphosphohydrolase.
@ast
Aicardi-Goutieres syndrome gen ...... ucleotide triphosphohydrolase.
@en
P2093
P2860
P3181
P356
P1476
Aicardi-Goutieres syndrome gen ...... ucleotide triphosphohydrolase.
@en
P2093
Fred W Perrino
Paul J Holland
Rebecca D Powell
Thomas Hollis
P2860
P304
43596-43600
P3181
P356
10.1074/JBC.C111.317628
P407
P577
2011-11-07T00:00:00Z