Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2
about
Deficient spindle assembly checkpoint in multiple myelomaHuman sperm sex chromosome disomy and sperm DNA damage assessed by the neutral comet assayImpairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomasCrystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpointFAT10 plays a role in the regulation of chromosomal stabilityTpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpointCentromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome lossIdentification of a MAD2-binding protein, CMT2, and its role in mitosis.APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachmentHec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint controlMTBP plays a crucial role in mitotic progression and chromosome segregationSil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpointMad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint.Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplicationCheckpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complexIdentification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulationA requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpointConformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpointLethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesisMammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpointsThe role of aneuploidy in promoting and suppressing tumorsCytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivationWhen 2+2=5: the origins and fates of aneuploid and tetraploid cellsSpindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activityBub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesisCyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphaseMad2 overexpression promotes aneuploidy and tumorigenesis in miceMG-132, an inhibitor of proteasomes and calpains, induced inhibition of oocyte maturation and aneuploidy in mouse oocytesBRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolutionRecent insights in nanotechnology-based drugs and formulations designed for effective anti-cancer therapyA quantitative model for cyclin-dependent kinase control of the cell cycle: revisitedDNA damage associated with mitosis and cytokinesis failureFunctional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisMouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential.Excess of miRNA-378a-5p perturbs mitotic fidelity and correlates with breast cancer tumourigenesis in vivoHormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosisNovel sfi1 alleles uncover additional functions for Sfi1p in bipolar spindle assembly and function.The C-terminal half of Saccharomyces cerevisiae Mad1p mediates spindle checkpoint function, chromosome transmission fidelity and CEN association.Aneuploid colon cancer cells have a robust spindle checkpoint
P2860
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P2860
Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2
description
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im Juni 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/06/09)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/06/09)
@nl
наукова стаття, опублікована в червні 2000
@uk
مقالة علمية (نشرت في 9-6-2000)
@ar
name
Chromosome missegregation and ...... itotic checkpoint protein Mad2
@ast
Chromosome missegregation and ...... itotic checkpoint protein Mad2
@en
Chromosome missegregation and ...... itotic checkpoint protein Mad2
@nl
type
label
Chromosome missegregation and ...... itotic checkpoint protein Mad2
@ast
Chromosome missegregation and ...... itotic checkpoint protein Mad2
@en
Chromosome missegregation and ...... itotic checkpoint protein Mad2
@nl
prefLabel
Chromosome missegregation and ...... itotic checkpoint protein Mad2
@ast
Chromosome missegregation and ...... itotic checkpoint protein Mad2
@en
Chromosome missegregation and ...... itotic checkpoint protein Mad2
@nl
P2093
P3181
P1433
P1476
Chromosome missegregation and ...... itotic checkpoint protein Mad2
@en
P2093
M. L. Scott
P. K. Sorger
R. Benezra
V. Liberal
P304
P3181
P356
10.1016/S0092-8674(00)80875-2
P407
P577
2000-06-09T00:00:00Z