Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells. - Test2 - elhamkhani - TriplyDB

Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells.

Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells.

http://www.wikidata.org/entity/Q33260827

about

In vivo veritas: using yeast to probe the biological functions of G-quadruplexes Telomerase reverse transcriptase moonlights: Therapeutic targets beyond telomerase Quantitative visualization of DNA G-quadruplex structures in human cells Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres.A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres.The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.An integrative biological approach to the analysis of tissue culture data: application to the antitumour agent RHPS4.Cation involvement in telomestatin binding to g-quadruplex DNA."One ring to bind them all"-part I: the efficiency of the macrocyclic scaffold for g-quadruplex DNA recognition.G-quadruplex nucleic acids and human disease A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells.RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.Advances in the molecular design of potential anticancer agents via targeting of human telomeric DNA.A small molecule inhibitor of Pot1 binding to telomeric DNA.p53 governs telomere regulation feedback too, via TRF2.Targeting DNA G-quadruplexes with helical small molecules.Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT-associated proteins G-quadruplexes significantly stimulate Pif1 helicase-catalyzed duplex DNA unwinding.G-quadruplexes: from guanine gels to chemotherapeutics The nickel(II) complex of guanidinium phenyl porphyrin, a specific G-quadruplex ligand, targets telomeres and leads to POT1 mislocalization in culture cells.A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region.Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA DNA helicases involved in DNA repair and their roles in cancer Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action Telomerase and its potential for therapeutic intervention.Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.Mechanism of the antiproliferative activity of some naphthalene diimide G-quadruplex ligands.FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase.Stability and kinetics of G-quadruplex structures Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells.A hitchhiker's guide to G-quadruplex ligands.Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability.Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.A G-quadruplex stabilizer induces M-phase cell cycle arrest Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb.

P2860

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P2860

Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells.

http://www.wikidata.org/entity/Q33260827

description

2006 nî lūn-bûn

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2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2006 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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Telomestatin-induced telomere ...... n in HT1080 human tumor cells.

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Telomestatin-induced telomere ...... n in HT1080 human tumor cells.

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Telomestatin-induced telomere ...... n in HT1080 human tumor cells.

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Telomestatin-induced telomere ...... n in HT1080 human tumor cells.

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Telomestatin-induced telomere ...... n in HT1080 human tumor cells.

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Telomestatin-induced telomere ...... n in HT1080 human tumor cells.

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Telomestatin-induced telomere ...... n in HT1080 human tumor cells.

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Telomestatin-induced telomere ...... n in HT1080 human tumor cells.

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Journal of Biological Chemistry

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Telomestatin-induced telomere ...... on in HT1080 human tumor cells

@en

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Bertrand Brassart

http://www.w3.org/2001/XMLSchema#string

Chantal Trentesaux

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Céline Douarre

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Dennis Gomez

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Hamid Morjani

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Kazuo Shin-Ya

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Thomas Wenner

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Victoria El Khoury

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P2860

Mammalian telomeres end in a large duplex loop

Normal human chromosomes have long G-rich telomeric overhangs at one end

Human POT1 facilitates telomere elongation by telomerase

Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.

POT1 and TRF2 cooperate to maintain telomeric integrity

Highly prevalent putative quadruplex sequence motifs in human DNA

Prevalence of quadruplexes in the human genome.

Telomere measurement by quantitative PCR

Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence

Creation of human tumour cells with defined genetic elements

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38721-38729

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scholarly article

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10.1074/JBC.M605828200

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50

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281

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Jean-François Riou

Marie-Francoise O'Donohue

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2006-10-17T00:00:00Z

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17050546

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