Human POT1 facilitates telomere elongation by telomerase
about
The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenancePTOP interacts with POT1 and regulates its localization to telomeresA critical role for TPP1 and TIN2 interaction in high-order telomeric complex assemblyReplication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeresTelosome, a mammalian telomere-associated complex formed by multiple telomeric proteinsThe human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activityPOT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substratesTelomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongationHuman protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitroPOT1 and TRF2 cooperate to maintain telomeric integrityRescue of an hTERT mutant defective in telomere elongation by fusion with hPot1Structure and function of the telomeric CST complexMultiple facets of TPP1 in telomere maintenanceInhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13pATM and ATR Signaling Regulate the Recruitment of Human Telomerase to TelomeresDNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sitesSwitching human telomerase on and off with hPOT1 protein in vitroFunctional interaction between telomere protein TPP1 and telomeraseStructure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protectionDynamics of protein binding to telomeres in living cells: implications for telomere structure and function.Cell cycle localization, dimerization, and binding domain architecture of the telomere protein cPot1.Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stabilityThe Arabidopsis Pot1 and Pot2 proteins function in telomere length homeostasis and chromosome end protectionAlterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alpha.Identification of the determinants for the specific recognition of single-strand telomeric DNA by Cdc13Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells.Tetrahymena POT1a regulates telomere length and prevents activation of a cell cycle checkpoint.Telomere maintenance through spatial control of telomeric proteinsArabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance.Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation.Suppression of hPOT1 in diploid human cells results in an hTERT-dependent alteration of telomere length dynamics.Nonadditivity in the recognition of single-stranded DNA by the schizosaccharomyces pombe protection of telomeres 1 DNA-binding domain, Pot1-DBDUtility of telomerase-pot1 fusion protein in vascular tissue engineering.Structural and functional analysis of the human POT1-TPP1 telomeric complex.Pot1 and telomere maintenance.Protection of Telomeres 1 is required for telomere integrity in the moss Physcomitrella patens.CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance.The effect of chemotherapeutic agents on telomere length maintenance in breast cancer cell lines.Human telomeres maintain their overhang length at senescence.Expression of telomere binding proteins in gastric cancer and correlation with clinicopathological parameters.
P2860
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P2860
Human POT1 facilitates telomere elongation by telomerase
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Human POT1 facilitates telomere elongation by telomerase
@ast
Human POT1 facilitates telomere elongation by telomerase
@en
Human POT1 facilitates telomere elongation by telomerase
@en-gb
Human POT1 facilitates telomere elongation by telomerase
@nl
type
label
Human POT1 facilitates telomere elongation by telomerase
@ast
Human POT1 facilitates telomere elongation by telomerase
@en
Human POT1 facilitates telomere elongation by telomerase
@en-gb
Human POT1 facilitates telomere elongation by telomerase
@nl
prefLabel
Human POT1 facilitates telomere elongation by telomerase
@ast
Human POT1 facilitates telomere elongation by telomerase
@en
Human POT1 facilitates telomere elongation by telomerase
@en-gb
Human POT1 facilitates telomere elongation by telomerase
@nl
P50
P3181
P1433
P1476
Human POT1 facilitates telomere elongation by telomerase
@en
P2093
Katherine Baran
Lorel M Colgin
P3181
P356
10.1016/S0960-9822(03)00339-7
P407
P577
2003-05-27T00:00:00Z