about
Reverse engineering of the spindle assembly checkpointShugoshin is a Mad1/Cdc20-like interactor of Mad2Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpointThe APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.Cycles and the qualitative evolution of chemical systemsBub1 and Bub3 promote the conversion from monopolar to bipolar chromosome attachment independently of shugoshinMolecular dynamics simulation on the conformational transition of the mad2 protein from the open to the closed state.Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase.Using default constraints of the spindle assembly checkpoint to estimate the associated chemical rates.Spatial-temporal model for silencing of the mitotic spindle assembly checkpointPhosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition.Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signalingBUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex.p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachmentClosed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC)Mad2 and Mad3 cooperate to arrest budding yeast in mitosis.Erroneous Silencing of the Mitotic Checkpoint by Aberrant Spindle Pole-Kinetochore Coordination.A quantitative systems view of the spindle assembly checkpoint.Overcoming inhibition in the spindle checkpoint.Spindle assembly checkpoint: the third decade.Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint.Spatial rule-based modeling: a method and its application to the human mitotic kinetochore.When Mad met Bub.A direct role of Mad1 in the spindle assembly checkpoint beyond Mad2 kinetochore recruitment.Regulation of mitotic progression by the spindle assembly checkpointConformation-specific anti-Mad2 monoclonal antibodies for the dissection of checkpoint signaling.In silico spatial simulations reveal that MCC formation and excess BubR1 are required for tight inhibition of the anaphase-promoting complex.Spindle assembly checkpoint is sufficient for complete Cdc20 sequestering in mitotic control.Systems Biology Modeling of Five Pathways for Regulation and Potent Inhibition of the Anaphase-Promoting Complex (APC/C): Pivotal Roles for MCC and BubR1.The mitotic checkpoint complex (MCC): looking back and forth after 15 years.A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint.Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeastActive transport can greatly enhance Cdc20:Mad2 formation.Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientationA dynamical model of the spindle position checkpoint.Basis of catalytic assembly of the mitotic checkpoint complex.The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding.Modeling the mitotic regulatory network identifies highly efficient anti-cancer drug combinations.Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing.Implications of alternative routes to APC/C inhibition by the mitotic checkpoint complex
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The influence of catalysis on mad2 activation dynamics.
@ast
The influence of catalysis on mad2 activation dynamics.
@en
type
label
The influence of catalysis on mad2 activation dynamics.
@ast
The influence of catalysis on mad2 activation dynamics.
@en
prefLabel
The influence of catalysis on mad2 activation dynamics.
@ast
The influence of catalysis on mad2 activation dynamics.
@en
P2093
P2860
P1433
P1476
The influence of catalysis on mad2 activation dynamics.
@en
P2093
Andrea Ciliberto
Bela Novak
Lucia Massimiliano
Marco Simonetta
Marina Mapelli
Martin Vink
Romilde Manzoni
P2860
P356
10.1371/JOURNAL.PBIO.1000010
P407
P577
2009-01-01T00:00:00Z