Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosis
about
Structural studies of CNG repeatsTwisting right to left: A…A mismatch in a CAG trinucleotide repeat overexpansion provokes left-handed Z-DNA conformationGFP-based fluorescence assay for CAG repeat instability in cultured human cellsProcessing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability.Expanded CAG/CTG repeat DNA induces a checkpoint response that impacts cell proliferation in Saccharomyces cerevisiae.Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells.Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1.Nucleotide excision repair, mismatch repair, and R-loops modulate convergent transcription-induced cell death and repeat instabilityBidirectional transcription stimulates expansion and contraction of expanded (CTG)*(CAG) repeats.Transcription elongation and tissue-specific somatic CAG instability.Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeatsEnvironmental stress induces trinucleotide repeat mutagenesis in human cells.A genome-wide map of adeno-associated virus-mediated human gene targetingStabilization of expanded (CTG)•(CAG) repeats by antisense oligonucleotides.Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability.Repeat instability during DNA repair: Insights from model systemsInstability of (CTG)n•(CAG)n trinucleotide repeats and DNA synthesisTranscription as a source of genome instability.Polyglutamine (polyQ) disorders: the chromatin connection.Somatic expansion in mouse and human carriers of fragile X premutation alleles.Oligodeoxynucleotide binding to (CTG) · (CAG) microsatellite repeats inhibits replication fork stalling, hairpin formation, and genome instability.Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs.Tissue-dependent regulation of RNAP II dynamics: the missing link between transcription and trinucleotide repeat instability in diseases?Expanded complexity of unstable repeat diseases.Transcription-induced DNA toxicity at trinucleotide repeats: double bubble is trouble.Mismatch repair enhances convergent transcription-induced cell death at trinucleotide repeats by activating ATR.R Loops and Links to Human Disease.Convergent transcription through microsatellite repeat tracts induces cell death.Antisense transcription of the myotonic dystrophy locus yields low-abundant RNAs with and without (CAG)n repeat.RNA toxicity and foci formation in microsatellite expansion diseases.Repair of chromosomal double-strand breaks by precise ligation in human cells.Close encounters: Moving along bumps, breaks, and bubbles on expanded trinucleotide tracts.Fanconi anemia pathway regulates convergent transcription-induced cell death at trinucleotide repeats in human cells.RNA biology of disease-associated microsatellite repeat expansions.Selection pressure on human STR loci and its relevance in repeat expansion disease.
P2860
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P2860
Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosis
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Convergent transcription throu ...... repeats and induces apoptosis
@ast
Convergent transcription throu ...... repeats and induces apoptosis
@en
type
label
Convergent transcription throu ...... repeats and induces apoptosis
@ast
Convergent transcription throu ...... repeats and induces apoptosis
@en
prefLabel
Convergent transcription throu ...... repeats and induces apoptosis
@ast
Convergent transcription throu ...... repeats and induces apoptosis
@en
P2093
P2860
P356
P1476
Convergent transcription throu ...... repeats and induces apoptosis
@en
P2093
P2860
P304
P356
10.1128/MCB.00332-10
P407
P577
2010-07-20T00:00:00Z