Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity. - Test2 - elhamkhani - TriplyDB

Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity.

Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity.

http://www.wikidata.org/entity/Q33936629

about

When the genome plays dice: circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitoses RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression Endopolyploidy in irradiated p53-deficient tumour cell lines: persistence of cell division activity in giant cells expressing Aurora-B kinase When 2+2=5: the origins and fates of aneuploid and tetraploid cells Sister chromatid decatenation: bridging the gaps in our knowledge The quiescent cellular state is Arf/p53-dependent and associated with H2AX downregulation and genome stability Therapeutic targeting of replicative immortality Contribution of soft substrates to malignancy and tumor suppression during colon cancer cell division Intratumour diversity of chromosome copy numbers in neuroblastoma mediated by on-going chromosome loss from a polyploid state Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells Stem cells, senescence, neosis and self-renewal in cancer.Elevated tolerance to aneuploidy in cancer cells: estimating the fitness effects of chromosome number alterations by in silico modelling of somatic genome evolution Phyllanthus emblica Fruit Extract Activates Spindle Assembly Checkpoint, Prevents Mitotic Aberrations and Genomic Instability in Human Colon Epithelial NCM460 Cells.Cross talk between estradiol and mTOR kinase in the regulation of ovarian granulosa proliferation MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy.Human cancer cells commonly acquire DNA damage during mitotic arrest.Generation of trisomies in cancer cells by multipolar mitosis and incomplete cytokinesis Whole chromosome gain does not in itself confer cancer-like chromosomal instability Overexpression of Srcin1 contributes to the growth and metastasis of colorectal cancer.p53 suppresses structural chromosome instability after mitotic arrest in human cells.Cytokinesis-blocked micronucleus cytome assay biomarkers identify lung cancer cases amongst smokers.PRL-3 promotes telomere deprotection and chromosomal instability.Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells mTOR controls ovarian follicle growth by regulating granulosa cell proliferation Complementary analysis of microsatellite tumor profile and mismatch repair defects in colorectal carcinomas.Ccq1p and the condensin proteins Cut3p and Cut14p prevent telomere entanglements in the fission yeast Schizosaccharomyces pombe.From aneuploidy to cancer: the evolution of a new species?Cancer chromosomal instability: therapeutic and diagnostic challenges.Shattered and stitched chromosomes-chromothripsis and chromoanasynthesis-manifestations of a new chromosome crisis?Cytokinesis breaks dicentric chromosomes preferentially at pericentromeric regions and telomere fusions.Genetic biomarkers for neoplastic colorectal cancer in peripheral lymphocytes PinX1: a sought-after major tumor suppressor at human chromosome 8p23 The cytokinesis-blocked micronucleus assay as a strong predictor of lung cancer: extension of a lung cancer risk prediction model Chromosome Bridges Maintain Kinetochore-Microtubule Attachment throughout Mitosis and Rarely Break during Anaphase Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice.Mitotic Origins of Chromosomal Instability in Colorectal Cancer.Abnormal micronuclear telomeres lead to an unusual cell cycle checkpoint and defects in Tetrahymena oral morphogenesis Telomere dysfunction and telomerase activation in cancer--a pathological paradox?v-Src Causes Chromosome Bridges in a Caffeine-Sensitive Manner by Generating DNA Damage Chromosome 9 arm-specific telomere length and breast cancer risk

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Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity.

http://www.wikidata.org/entity/Q33936629

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2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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Structural and numerical chrom ...... through mitotic multipolarity.

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Structural and numerical chrom ...... through mitotic multipolarity.

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Structural and numerical chrom ...... through mitotic multipolarity.

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Structural and numerical chrom ...... through mitotic multipolarity.

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Structural and numerical chrom ...... through mitotic multipolarity.

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Structural and numerical chrom ...... through mitotic multipolarity.

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David Gisselsson

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Felix Mitelman

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Ludmila Gorunova

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Nils Mandahl

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Nina Larsson

http://www.w3.org/2001/XMLSchema#string

Tord Jonson

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Ylva Stewénius

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P2860

Mutations of mitotic checkpoint genes in human cancers

The Stability of Broken Ends of Chromosomes in Zea Mays.

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

Centrosomal abnormalities, multipolar mitoses, and chromosomal instability in head and neck tumours with dysfunctional telomeres

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

Genetic instability in colorectal cancers

Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations

Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors.

Telomere reduction in human colorectal carcinoma and with ageing.

Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC

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102

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Fredrik Mertens

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7927706

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556242

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