about
Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substratesChk1 suppressed cell deathThe F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stressBID binds to replication protein A and stimulates ATR function following replicative stressCommon mechanisms of PIKK regulationThe Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathwaysGenetic spell-checking: gene editing using single-stranded DNA oligonucleotidesStructure of a DNA Polymerase -Primase Domain That Docks on the SV40 Helicase and Activates the Viral PrimosomeDNA damage control: regulation and functions of checkpoint kinase 1RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.ATR: an essential regulator of genome integrityTelomere protection by TPP1/POT1 requires tethering to TIN2Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis.Importance of a C-terminal conserved region of Chk1 for checkpoint function.Global regulation of genome duplication in eukaryotes: an overview from the epifluorescence microscope.The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.Network architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis.Physical interaction between replication protein A (RPA) and MRN: involvement of RPA2 phosphorylation and the N-terminus of RPA1.Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.Ataxin-3 promotes genome integrity by stabilizing Chk1.The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint responseInteractions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment.A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion.Continued primer synthesis at stalled replication forks contributes to checkpoint activation.Analysis of histones and chromatin in Xenopus laevis egg and oocyte extracts.ATR autophosphorylation as a molecular switch for checkpoint activation.Xenopus laevis Ctc1-Stn1-Ten1 (xCST) protein complex is involved in priming DNA synthesis on single-stranded DNA template in Xenopus egg extract.Role of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts.Brc1-dependent recovery from replication stress.Removing all obstacles: a critical role for p53 in promoting tissue renewalDown-regulation of replication factor C-40 (RFC40) causes chromosomal missegregation in neonatal and hypertrophic adult rat cardiac myocytes.Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response.Causes and consequences of replication stress.Initiation of DNA damage responses through XPG-related nucleasesTRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.Replication licensing and the DNA damage checkpoint.Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1.DNA structure-specific priming of ATR activation by DNA-PKcs
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The structural determinants of checkpoint activation
@ast
The structural determinants of checkpoint activation
@en
The structural determinants of checkpoint activation
@nl
type
label
The structural determinants of checkpoint activation
@ast
The structural determinants of checkpoint activation
@en
The structural determinants of checkpoint activation
@nl
prefLabel
The structural determinants of checkpoint activation
@ast
The structural determinants of checkpoint activation
@en
The structural determinants of checkpoint activation
@nl
P2093
P2860
P356
P1433
P1476
The structural determinants of checkpoint activation
@en
P2093
Christina A MacDougall
Christopher Van
Karlene A Cimprich
Muh-ching Yee
Tony S Byun
P2860
P304
P356
10.1101/GAD.1522607
P577
2007-04-01T00:00:00Z