3'-phosphodiesterase activity of human apurinic/apyrimidinic endonuclease at DNA double-strand break ends
about
Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoterConversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate endsActivation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicalsXRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactionsDeficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)Inhibition of Ape1 nuclease activity by lead, iron, and cadmium.Human AP endonuclease 1: a potential marker for the prediction of environmental carcinogenesis riskOverview of base excision repair biochemistrySolution structure of an oligonucleotide containing an abasic site: evidence for an unusual deoxyribose conformationSynthesis, characterization and solution structure of tethered oligonucleotides containing an internal 3'-phosphoglycolate, 5'-phosphate gapped lesionAP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesisStimulation of 3'-->5' exonuclease and 3'-phosphodiesterase activities of yeast apn2 by proliferating cell nuclear antigen.3'-phosphodiesterase and 3'-->5' exonuclease activities of yeast Apn2 protein and requirement of these activities for repair of oxidative DNA damage.Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.Processing of damaged DNA ends for double-strand break repair in mammalian cellsHuman Ape2 protein has a 3'-5' exonuclease activity that acts preferentially on mismatched base pairsDynamics of the interaction of human apurinic endonuclease (Ape1) with its substrate and productA quantitative model of human DNA base excision repair. I. Mechanistic insights.Mutations in the alpha8 loop of human APE1 alter binding and cleavage of DNA containing an abasic site.Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding.Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria.In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutationIn vitro repair of complex unligatable oxidatively induced DNA double-strand breaks by human cell extracts.Patching and single-strand ligation in nonhomologous DNA end joining despite persistence of a closely opposed 3'-phosphoglycolate-terminated strand break.Small molecule inhibitors of DNA repair nuclease activities of APE1.Polynucleotide kinase as a potential target for enhancing cytotoxicity by ionizing radiation and topoisomerase I inhibitorsChinese hamster apurinic/apyrimidinic endonuclease (chAPE1) expressed in sf9 cells reveals that its endonuclease activity is regulated by phosphorylation.Structural insights by molecular dynamics simulations into specificity of the major human AP endonuclease toward the benzene-derived DNA adduct, pBQ-C.Distinct roles of Ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin.Elements in abasic site recognition by the major human and Escherichia coli apurinic/apyrimidinic endonucleases.DNA repair mechanisms in dividing and non-dividing cells.Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.Exploiting base excision repair to improve therapeutic approaches for pancreatic cancerSIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clampUbiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stabilityWRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups.Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigmsBleomycins: towards better therapeutics.Characterization of the endoribonuclease active site of human apurinic/apyrimidinic endonuclease 1.
P2860
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P2860
3'-phosphodiesterase activity of human apurinic/apyrimidinic endonuclease at DNA double-strand break ends
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
3'-phosphodiesterase activity ...... t DNA double-strand break ends
@ast
3'-phosphodiesterase activity ...... t DNA double-strand break ends
@en
3'-phosphodiesterase activity ...... t DNA double-strand break ends
@nl
type
label
3'-phosphodiesterase activity ...... t DNA double-strand break ends
@ast
3'-phosphodiesterase activity ...... t DNA double-strand break ends
@en
3'-phosphodiesterase activity ...... t DNA double-strand break ends
@nl
prefLabel
3'-phosphodiesterase activity ...... t DNA double-strand break ends
@ast
3'-phosphodiesterase activity ...... t DNA double-strand break ends
@en
3'-phosphodiesterase activity ...... t DNA double-strand break ends
@nl
P2093
P2860
P356
P1476
3'-phosphodiesterase activity ...... t DNA double-strand break ends
@en
P2093
P2860
P304
P356
10.1093/NAR/25.12.2495
P407
P577
1997-06-01T00:00:00Z