The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor.
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The HIV1 protein Vpr acts to enhance constitutive DCAF1-dependent UNG2 turnoverThe CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative regulator of NF-κB, pyrin-only protein 4VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelityHIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasomeInvolvement of Lgl and Mahjong/VprBP in cell competitionVpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tailFormation of mobile chromatin-associated nuclear foci containing HIV-1 Vpr and VPRBP is critical for the induction of G2 cell cycle arrestVisualizing Vpr-induced G2 arrest and apoptosisStructural basis of lentiviral subversion of a cellular protein degradation pathwayHow SLX4 cuts through the mystery of HIV-1 Vpr-mediated cell cycle arrest.The DDB1-DCAF1-Vpr-UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destructionDistinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4BCullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complexLentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infectionCharacterization of the molecular determinants of primary HIV-1 Vpr proteins: impact of the Q65R and R77Q substitutions on Vpr functions.Sequencing, analysis, and annotation of expressed sequence tags for Camelus dromedariusHIV-1 Vpr inhibits cytokinesis in human proximal tubule cellsInteractions with DCAF1 and DDB1 in the CRL4 E3 ubiquitin ligase are required for Vpr-mediated G2 arrest.Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytesVpr-host interactions during HIV-1 viral life cycle.HIV-1 Vpr and G2 cell cycle arrest.The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection.Exposed hydrophobic residues in human immunodeficiency virus type 1 Vpr helix-1 are important for cell cycle arrest and cell deathAPOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing.HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation.HIV-1 Vpr triggers mitochondrial destruction by impairing Mfn2-mediated ER-mitochondria interaction.Thriving under stress: selective translation of HIV-1 structural protein mRNA during Vpr-mediated impairment of eIF4E translation activity.Cullins and cancer.HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication.The Cullin-RING E3 ubiquitin ligase CRL4-DCAF1 complex dimerizes via a short helical region in DCAF1.Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development.HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic interventionHIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP.Human immunodeficiency virus type 1 Vif causes dysfunction of Cdk1 and CyclinB1: implications for cell cycle arrest.Understanding the molecular manipulation of DCAF1 by the lentiviral accessory proteins Vpr and Vpx.Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon.Defining the interactions and role of DCAF1/VPRBP in the DDB1-cullin4A E3 ubiquitin ligase complex engaged by HIV-1 Vpr to induce a G2 cell cycle arrest.Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response
P2860
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P2860
The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The HIV1 protein Vpr acts to p ...... ing VprBP/DCAF1 as an adaptor.
@ast
The HIV1 protein Vpr acts to p ...... ing VprBP/DCAF1 as an adaptor.
@en
The HIV1 protein Vpr acts to p ...... ing VprBP/DCAF1 as an adaptor.
@nl
type
label
The HIV1 protein Vpr acts to p ...... ing VprBP/DCAF1 as an adaptor.
@ast
The HIV1 protein Vpr acts to p ...... ing VprBP/DCAF1 as an adaptor.
@en
The HIV1 protein Vpr acts to p ...... ing VprBP/DCAF1 as an adaptor.
@nl
prefLabel
The HIV1 protein Vpr acts to p ...... ing VprBP/DCAF1 as an adaptor.
@ast
The HIV1 protein Vpr acts to p ...... ing VprBP/DCAF1 as an adaptor.
@en
The HIV1 protein Vpr acts to p ...... ing VprBP/DCAF1 as an adaptor.
@nl
P2093
P2860
P356
P1476
The HIV1 protein Vpr acts to p ...... ing VprBP/DCAF1 as an adaptor.
@en
P2093
Carlos M C de Noronha
Karen M Duus
Thomas D Friedrich
Xiaoyun Wen
P2860
P304
27046-27057
P356
10.1074/JBC.M703955200
P407
P577
2007-07-09T00:00:00Z