Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. - Test2 - elhamkhani - TriplyDB

Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development.

Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development.

http://www.wikidata.org/entity/Q34793207

about

VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins Ubiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancer The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression VprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligases CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases.Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons.Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response VprBP Is Required for Efficient Editing and Selection of Igκ+ B Cells, but Is Dispensable for Igλ+ and Marginal Zone B Cell Maturation and Selection.Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex.CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis A complex containing the CPSF73 endonuclease and other polyadenylation factors associates with U7 snRNP and is recruited to histone pre-mRNA for 3'-end processing.DCAF1 controls T-cell function via p53-dependent and -independent mechanisms A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells.Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells.Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases Viral takeover of the host ubiquitin system.Merlin, a multi-suppressor from cell membrane to the nucleus.Lentivirus Vpr and Vpx accessory proteins usurp the cullin4-DDB1 (DCAF1) E3 ubiquitin ligase.The Multifunctions of WD40 Proteins in Genome Integrity and Cell Cycle Progression.SLX4-SLX1 Protein-independent Down-regulation of MUS81-EME1 Protein by HIV-1 Viral Protein R (Vpr).VprBP/DCAF1 Regulates the Degradation and Nonproteolytic Activation of the Cell Cycle Transcription Factor FoxM1.Underlying mechanisms of HIV-1 latency.HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrest Vpr overcomes macrophage-specific restriction of HIV-1 Env expression and virion production A first-in-class NAE inhibitor, MLN4924, blocks lentiviral infection in myeloid cells by disrupting neddylation-dependent Vpx-mediated SAMHD1 degradation.Molecular insight into how HIV-1 Vpr protein impairs cell growth through two genetically distinct pathways.Targeting protein ubiquitylation: DDB1 takes its RING off DNA damage checkpoint responses in the S phase of synchronized diploid human fibroblasts.Arabidopsis CULLIN4-damaged DNA binding protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time.DCAF1 is involved in HCV replication through regulation of miR-122.

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Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development.

http://www.wikidata.org/entity/Q34793207

description

2008 nî lūn-bûn

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2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2008 թվականի հուլիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Human immunodeficiency virus t ...... ion and embryonic development.

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Human immunodeficiency virus t ...... ion and embryonic development.

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Human immunodeficiency virus t ...... ion and embryonic development.

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Human immunodeficiency virus t ...... ion and embryonic development.

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Human immunodeficiency virus t ...... ion and embryonic development.

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Human immunodeficiency virus t ...... ion and embryonic development.

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Human immunodeficiency virus t ...... ion and embryonic development.

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Human immunodeficiency virus t ...... ion and embryonic development.

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Human immunodeficiency virus t ...... ion and embryonic development.

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Molecular and Cellular Biology

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Human immunodeficiency virus t ...... ion and embryonic development.

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Chad M McCall

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Jeanette Gowen Cook

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Paul D Chastain

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Paula L Miliani de Marval

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Sarah C Jackson

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Yizhou J He

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Yojiro Kotake

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Yue Xiong

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P2860

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest

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5621-5633

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scholarly article

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10.1128/MCB.00232-08

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18

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28

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2008-07-07T00:00:00Z

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5245787

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18606781

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2546929

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