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Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

http://www.wikidata.org/entity/Q34771016

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Diversity-oriented synthetic strategies applied to cancer chemical biology and drug discovery Small molecule tools for functional interrogation of protein tyrosine phosphatases Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB Natural-product-derived fragments for fragment-based ligand discovery Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase B (PtpB) inhibitors from natural products Towards the optimal screening collection: a synthesis strategy Interdisciplinary Comprehensive Arm Rehabilitation Evaluation (ICARE): a randomized controlled trial protocol.Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages.Principles, implementation, and application of biology-oriented synthesis (BIOS).Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents.Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands Diversity-oriented synthesis of macrocyclic peptidomimetics.Design, synthesis, and bioactivities screening of a diaryl ketone-inspired pesticide molecular library as derived from natural products.Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.Multicomponent reaction design in the quest for molecular complexity and diversity.Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.Towards the systematic exploration of chemical space.Therapeutic potential of targeting the oncogenic SHP2 phosphatase.Biology-oriented synthesis.Synthesis of azaphilone-based chemical libraries Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis.Is synthesis the main hurdle for the generation of diversity in compound libraries for screening?Synthesis of privileged scaffolds by using diversity-oriented synthesis.A facile hydroxyindole carboxylic acid based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase B Discovery of neuritogenic compound classes inspired by natural products.Targeting protein tyrosine phosphatases for anticancer drug discovery.Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway.Hydroxyindole carboxylic acid-based inhibitors for receptor-type protein tyrosine protein phosphatase beta Double click reaction for the acquisition of a highly potent and selective mPTPB inhibitor Protein tyrosine phosphatase PtpA is not required for Mycobacterium tuberculosis growth in mice.Carbohydrates in diversity-oriented synthesis: challenges and opportunities.Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis.Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.New approaches to molecular cancer therapeutics.Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.New strategies in fighting TB: targeting Mycobacterium tuberculosis-secreted phosphatases MptpA & MptpB.Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development.Elimination of intracellularly residing Mycobacterium tuberculosis through targeting of host and bacterial signaling mechanisms.

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P2860

Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

http://www.wikidata.org/entity/Q34771016

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Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

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Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

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Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

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Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation

VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts

CDC25 phosphatases as potential human oncogenes

Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2

A planning strategy for diversity-oriented synthesis

Protein tyrosine phosphatases in the human genome

Signaling--2000 and beyond

Compound library development guided by protein structure similarity clustering and natural product structure

Protein structure similarity clustering and natural product structure as guiding principles in drug discovery.

Charting biologically relevant chemical space: a structural classification of natural products (SCONP)

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