Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice
about
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cellsEpigenetic perturbations in aging stem cellsEpigenetic genome-wide association methylation in aging and longevityThe hallmarks of agingPotential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseasesMsl2 is a novel component of the vertebrate DNA damage responseCurrent aging research in China.HP1α mediates defective heterochromatin repair and accelerates senescence in Zmpste24-deficient cells.DNA damage and laminsStem cell aging: mechanisms, regulators and therapeutic opportunities.NuA4 initiates dynamic histone H4 acetylation to promote high-fidelity sister chromatid recombination at postreplication gaps.The role of DNA damage in laminopathy progeroid syndromes.Chromatin remodeling, DNA damage repair and aging.DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome.Methods to Monitor DNA Repair Defects and Genomic Instability in the Context of a Disrupted Nuclear Lamina.'Relax and Repair' to restrain aging.MicroRNA transcriptome analysis identifies miR-365 as a novel negative regulator of cell proliferation in Zmpste24-deficient mouse embryonic fibroblasts.BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylationNesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageingCdc42 activity regulates hematopoietic stem cell aging and rejuvenation.Histone H4 lysine 20 acetylation is associated with gene repression in human cellsMutant lamin A links prophase to a p53 independent senescence program.Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria SyndromeFamilial partial lipodystrophy, mandibuloacral dysplasia and restrictive dermopathy feature barrier-to-autointegration factor (BAF) nuclear redistribution.Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies.Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.Deacetylation of H4-K16Ac and heterochromatin assembly in senescence.The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging.ATM and KAT5 safeguard replicating chromatin against formaldehyde damage.Epigenetic regulation of ageing: linking environmental inputs to genomic stability.MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis.Nuclear lamin functions and disease.MOF maintains transcriptional programs regulating cellular stress response.Barrier-to-autointegration factor (BAF) involvement in prelamin A-related chromatin organization changes.Chromatin remodeling of human subtelomeres and TERRA promoters upon cellular senescence: commonalities and differences between chromosomesExpression, purification and proteomic analysis of recombinant histone H4 acetylated at lysine 16.Chromatin modifications associated with DNA double-strand breaks repair as potential targets for neurological diseases.Chromatin structure and transposable elements in organismal aging.Adult Stem Cells and Diseases of Aging.
P2860
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P2860
Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Histone H4 lysine 16 hypoacety ...... nce in Zmpste24-deficient mice
@ast
Histone H4 lysine 16 hypoacety ...... nce in Zmpste24-deficient mice
@en
type
label
Histone H4 lysine 16 hypoacety ...... nce in Zmpste24-deficient mice
@ast
Histone H4 lysine 16 hypoacety ...... nce in Zmpste24-deficient mice
@en
prefLabel
Histone H4 lysine 16 hypoacety ...... nce in Zmpste24-deficient mice
@ast
Histone H4 lysine 16 hypoacety ...... nce in Zmpste24-deficient mice
@en
P2093
P2860
P921
P356
P1476
Histone H4 lysine 16 hypoacety ...... nce in Zmpste24-deficient mice
@en
P2093
Baohua Liu
Maggie Zi Ying Chow
Vaidehi Krishnan
Xinguang Liu
Zimei Wang
P2860
P304
12325-12330
P356
10.1073/PNAS.1102789108
P407
P577
2011-07-11T00:00:00Z