Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor.
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New insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptorsStructural and energetic effects of A2A adenosine receptor mutations on agonist and antagonist bindingStructure-Based Design of Reactive Nucleosides for Site-Specific Modification of the A2A Adenosine ReceptorConformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptorStructure-based approaches to ligands for G-protein-coupled adenosine and P2Y receptors, from small molecules to nanoconjugates.Molecular docking screening using agonist-bound GPCR structures: probing the A2A adenosine receptor.The discovery of a selective and potent A2a agonist with extended lung retention.Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.Probing GPCR structure: adenosine and P2Y nucleotide receptors.The GPCR Network: a large-scale collaboration to determine human GPCR structure and function.Crystal structures of the A2A adenosine receptor and their use in medicinal chemistry.Structure-based and fragment-based GPCR drug discovery.Novel approaches for targeting the adenosine A2A receptor.Structure-Activity Relationships of the Sustained Effects of Adenosine A2A Receptor Agonists Driven by Slow Dissociation Kinetics.Graph analysis of β2 adrenergic receptor structures: a "social network" of GPCR residues.Conserved disulfide bond is not essential for the adenosine A2A receptor: Extracellular cysteines influence receptor distribution within the cell and ligand-binding recognition.Breakthrough in GPCR Crystallography and Its Impact on Computer-Aided Drug Design.New selective A2A agonists and A3 antagonists for human adenosine receptors: synthesis, biological activity and molecular docking studies
P2860
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P2860
Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Evaluation of molecular modeli ...... -bound A₂A adenosine receptor.
@ast
Evaluation of molecular modeli ...... -bound A₂A adenosine receptor.
@en
type
label
Evaluation of molecular modeli ...... -bound A₂A adenosine receptor.
@ast
Evaluation of molecular modeli ...... -bound A₂A adenosine receptor.
@en
prefLabel
Evaluation of molecular modeli ...... -bound A₂A adenosine receptor.
@ast
Evaluation of molecular modeli ...... -bound A₂A adenosine receptor.
@en
P2093
P2860
P50
P356
P1476
Evaluation of molecular modeli ...... -bound A₂A adenosine receptor.
@en
P2093
Francesca Deflorian
Raymond C Stevens
T Santhosh Kumar
P2860
P304
P356
10.1021/JM201461Q
P407
P577
2011-12-12T00:00:00Z