Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin. - Test2 - elhamkhani - TriplyDB

Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin.

Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin.

http://www.wikidata.org/entity/Q36562894

about

Nijmegen breakage syndrome (NBS)Phosphorylation: the molecular switch of double-strand break repair CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications BRCT domains: easy as one, two, three Ubc13: the Lys63 ubiquitin chain building machine The Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondii A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response Targeting the Checkpoint to Kill Cancer Cells Targeting ATM-deficient CLL through interference with DNA repair pathways The Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changes Structure of a Second BRCT Domain Identified in the Nijmegen Breakage Syndrome Protein Nbs1 and its Function in an MDC1-Dependent Localization of Nbs1 to DNA Damage Sites Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator Dimerization, but not phosphothreonine binding, is conserved between the forkhead-associated domains of Drosophila MU2 and human MDC1 Structural Insights into Recognition of MDC1 by TopBP1 in DNA Replication Checkpoint Control The DNA Damage Response: Making It Safe to Play with Knives Ancient and recent adaptive evolution of primate non-homologous end joining genes Autophosphorylation and ATM activation: additional sites add to the complexity.And-1 is required for homologous recombination repair by regulating DNA end resection.MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.Mediator of DNA damage checkpoint 1 (MDC1) contributes to high NaCl-induced activation of the osmoprotective transcription factor TonEBP/OREBP.Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair.The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination.Time to bloom.DNA double-strand break signaling and human disorders.The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair.Spatiotemporal dynamics of early DNA damage response proteins on complex DNA lesions.Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) Signaling MDC1 collaborates with TopBP1 in DNA replication checkpoint control.Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response.Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.

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P2860

Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin.

http://www.wikidata.org/entity/Q36562894

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Phosphorylation of SDT repeats ...... DNA damage-modified chromatin.

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Phosphorylation of SDT repeats ...... DNA damage-modified chromatin.

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type

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Phosphorylation of SDT repeats ...... DNA damage-modified chromatin.

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Phosphorylation of SDT repeats ...... DNA damage-modified chromatin.

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prefLabel

Phosphorylation of SDT repeats ...... DNA damage-modified chromatin.

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Phosphorylation of SDT repeats ...... DNA damage-modified chromatin.

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Phosphorylation of SDT repeats ...... DNA damage-modified chromatin.

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Fredrik Melander

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Jacob Falck

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Niels Mailand

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P2860

MDC1 is a mediator of the mammalian DNA damage checkpoint

APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

Large-scale characterization of HeLa cell nuclear phosphoproteins

A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses

The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

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2

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181

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Simon Bekker-Jensen

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5442009

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18411307

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phosphorylation

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2315670

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