Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves - Test2 - elhamkhani - TriplyDB

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

http://www.wikidata.org/entity/Q36804954

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Alzheimer's disease as homeostatic responses to age-related myelin breakdown Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs Amyloid Proteins and Their Role in Multiple Sclerosis. Considerations in the Use of Amyloid-PET Imaging Wallerian degeneration: the innate-immune response to traumatic nerve injury New insights on Schwann cell development Role of platelets in neuroinflammation: a wide-angle perspective Ferulic acid is a nutraceutical β-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic mice The normal and pathologic roles of the Alzheimer's β-secretase, BACE1 Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.BACE1 deficiency causes altered neuronal activity and neurodegeneration.BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2 Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.The secretases: enzymes with therapeutic potential in Alzheimer disease.TACE (ADAM17) inhibits Schwann cell myelination.β-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins.Inhibition of BACE1 for therapeutic use in Alzheimer's disease.Potential therapeutic strategies for Alzheimer's disease targeting or beyond β-amyloid: insights from clinical trials The mouse median nerve experimental model in regenerative research.Divalent cation tolerance protein binds to β-secretase and inhibits the processing of amyloid precursor protein.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Peripheral axons of the adult zebrafish maxillary barbel extensively remyelinate during sensory appendage regeneration.Targeting the β secretase BACE1 for Alzheimer's disease therapy.Methylene blue modulates β-secretase, reverses cerebral amyloidosis, and improves cognition in transgenic mice.Reduced sodium channel Na(v)1.1 levels in BACE1-null mice APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent manner.Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination.Axonal and Schwann cell BACE1 is equally required for remyelination of peripheral nerves.Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system.Development of a specific ELISA to measure BACE1 levels in human tissues.The keystone of Alzheimer pathogenesis might be sought in Aβ physiology Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation.Erbin is required for myelination in regenerated axons after injury.Reversing hypomyelination in BACE1-null mice with Akt-DD overexpression.Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling.Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.Is the amyloid hypothesis of Alzheimer's disease therapeutically relevant?β-Secretase: its biology as a therapeutic target in diseases Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease

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P2860

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

http://www.wikidata.org/entity/Q36804954

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Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

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Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

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Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

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Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

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Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

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Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

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Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

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Claudiu Diaconu

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Grahame J Kidd

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Riqiang Yan

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Wanxia He

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Wendy B Macklin

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Xiangyou Hu

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Xiaoying Tang

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P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

Purification and cloning of amyloid precursor protein beta-secretase from human brain

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

Control of peripheral nerve myelination by the beta-secretase BACE1

Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation

Axonal neuregulin-1 regulates myelin sheath thickness

A critical role for dorsal progenitors in cortical myelination

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18413858

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