Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends.
about
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repairHuman Dna2 is a nuclear and mitochondrial DNA maintenance proteinOkazaki fragment processing-independent role for human Dna2 enzyme during DNA replicationDNA resection in eukaryotes: deciding how to fix the breakDNA end resection: many nucleases make light workCollision of Trapped Topoisomerase 2 with Transcription and Replication: Generation and Repair of DNA Double-Strand Breaks with 5' AdductsDna2 exhibits a unique strand end-dependent helicase function.Identification of nucleases and phosphatases by direct biochemical screen of the Saccharomyces cerevisiae proteome.MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complexXenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATMMechanism for CCC DNA synthesis in hepadnaviruses.Significance of the dissociation of Dna2 by flap endonuclease 1 to Okazaki fragment processing in Saccharomyces cerevisiae.Defective resection at DNA double-strand breaks leads to de novo telomere formation and enhances gene targetingDna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates.Replication protein A promotes 5'-->3' end processing during homology-dependent DNA double-strand break repairCdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repairRole of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts.Analysis of MRE11's function in the 5'-->3' processing of DNA double-strand breaksDNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cellsInitiation of DNA damage responses through XPG-related nucleasesDNA end resection--unraveling the tail.Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2.DNA2 drives processing and restart of reversed replication forks in human cells.Mechanistic analysis of Xenopus EXO1's function in 5'-strand resection at DNA double-strand breaks.WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts.14-3-3 proteins restrain the Exo1 nuclease to prevent overresection.The N-terminus of RPA large subunit and its spatial position are important for the 5'->3' resection of DNA double-strand breaks.A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to ChemotherapyDNA double-strand breaks with 5' adducts are efficiently channeled to the DNA2-mediated resection pathway.Sharpening the ends for repair: mechanisms and regulation of DNA resection.The BLM dissolvasome in DNA replication and repair.The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair.Mechanism and regulation of DNA end resection in eukaryotesPCNA promotes processive DNA end resection by Exo1.The MRE11 complex: starting from the ends.Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes.Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection.Exonuclease 1 and its versatile roles in DNA repair.DNA2-An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein?Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells.
P2860
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P2860
Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Identification of the Xenopus ...... ecific processing of DNA ends.
@en
type
label
Identification of the Xenopus ...... ecific processing of DNA ends.
@en
prefLabel
Identification of the Xenopus ...... ecific processing of DNA ends.
@en
P2093
P2860
P356
P1476
Identification of the Xenopus ...... ecific processing of DNA ends.
@en
P2093
Shuren Liao
Thomas Toczylowski
P2860
P304
P356
10.1093/NAR/GKN616
P407
P577
2008-09-27T00:00:00Z