Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling. - Test2 - elhamkhani - TriplyDB

Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.

Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.

http://www.wikidata.org/entity/Q37621033

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OTULIN restricts Met1-linked ubiquitination to control innate immune signaling Regulation of Met1-linked polyubiquitin signalling by the deubiquitinase OTULIN Regulation of Cell Death by IAPs and Their Antagonists NOD-Like Receptors: Master Regulators of Inflammation and Cancer Ubiquitin in the immune system Cancers Related to Immunodeficiencies: Update and Perspectives CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation.Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency NOD1 and NOD2: signaling, host defense, and inflammatory disease.BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella.The diagnostic challenge of very early-onset enterocolitis in an infant with XIAP deficiency Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors.USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B-cell lymphoma.Familial hemophagocytic lymphohistiocytosis: when rare diseases shed light on immune system functioning.Immune diseases caused by mutations in kinases and components of the ubiquitin system.Met1-linked ubiquitination in immune signalling.X-linked inhibitor of apoptosis protein deficiency: more than an X-linked lymphoproliferative syndrome.Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system.Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease.How genetic testing can lead to targeted management of XIAP deficiency-related inflammatory bowel disease.Linear ubiquitin chains: enzymes, mechanisms and biology Diverse ubiquitin linkages regulate RIP kinases-mediated inflammatory and cell death signaling.SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.XIAP deficiency and MEFV variants resulting in an autoinflammatory lymphoproliferative syndrome.Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease.Symptomatic males and female carriers in a large Caucasian kindred with XIAP deficiency.Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders.XIAP variants in male Crohn's disease.Novel X-Linked Inhibitor of Apoptosis Mutation in Very Early-Onset Inflammatory Bowel Disease Child Successfully Treated with HLA-Haploidentical Hemapoietic Stem Cells Transplant after Removal of αβ+ T and B Cells.Epstein-Barr Virus and Hemophagocytic Lymphohistiocytosis.A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production.Molecular modeling in the age of clinical genomics, the enterprise of the next generation.A female patient with incomplete hemophagocytic lymphohistiocytosis caused by a heterozygous XIAP mutation associated with non-random X-chromosome inactivation skewed towards the wild-type XIAP allele.A new functional assay for the diagnosis of X-linked inhibitor of apoptosis (XIAP) deficiency.A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways.Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes.Inherited Immunodeficiencies With High Predisposition to Epstein–Barr Virus-Driven Lymphoproliferative Diseases.

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Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.

http://www.wikidata.org/entity/Q37621033

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on July 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Disease-causing mutations in t ...... 2-dependent immune signalling.

@en

Disease-causing mutations in t ...... 2-dependent immune signalling.

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type

label

Disease-causing mutations in t ...... 2-dependent immune signalling.

@en

Disease-causing mutations in t ...... 2-dependent immune signalling.

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prefLabel

Disease-causing mutations in t ...... 2-dependent immune signalling.

@en

Disease-causing mutations in t ...... 2-dependent immune signalling.

@nl

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EMBO Molecular Medicine

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Disease-causing mutations in t ...... 2-dependent immune signalling.

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Berthe Katrine Fiil

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Monica Yabal

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Niels Mailand

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Philipp J Jost

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Stephan Ehl

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P2860

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

Revisiting Crohn's disease as a primary immunodeficiency of macrophages

Structural basis for the inhibition of caspase-3 by XIAP

IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling

Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity

Linear ubiquitination prevents inflammation and regulates immune signalling

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

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1278-1295

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scholarly article

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10.1002/EMMM.201303090

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8

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5

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Simon Bekker-Jensen

Mads Gyrd-Hansen

Rune Busk Damgaard

Carsten Speckmann

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2013-07-01T00:00:00Z

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244482100

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23818254

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3944466

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