Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions.
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Small-molecule inhibitors of the Myc oncoproteinFragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain LigandsCyclin-Dependent Kinase Inhibitor Dinaciclib Interacts with the Acetyl-Lysine Recognition Site of BromodomainsAcetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase InhibitorsDiscovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors4-Acyl pyrroles: mimicking acetylated lysines in histone code readingStructure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain InhibitorsStructure-Based Design of an in Vivo Active Selective BRD9 InhibitorDrug Discovery Targeting Bromodomain-Containing Protein 4.The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network.Epigenetic control of gene function in schistosomes: a source of therapeutic targets?BET bromodomain inhibitors: a patent review.[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomainsSmall-molecular modulators of cancer-associated epigenetic mechanisms.Perturbation of the c-Myc-Max protein-protein interaction via synthetic α-helix mimetics.BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle.State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation.Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability.Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction.Targeting the epigenetic readers in Ewing sarcoma inhibits the oncogenic transcription factor EWS/Fli1.Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.Phenotypic screening and fragment-based approaches to the discovery of small-molecule bromodomain ligands.Bromodomains and their pharmacological inhibitors.Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.Progress in the Development of non-BET Bromodomain Chemical Probes.Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology.Bromodomain and extra-terminal (BET) family proteins: New therapeutic targets in major diseases.Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle.WONKA: objective novel complex analysis for ensembles of protein-ligand structures.1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain.A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction.Protein dynamics and structural waters in bromodomains.Structured water molecules in the binding site of bromodomains can be displaced by cosolvent.Conference scene: 2nd cancer epigenetics conference.A theoretical insight into selectivity of inhibitors toward two domains of bromodomain-containing protein 4 using molecular dynamics simulations.Does bromodomain flexibility influence histone recognition?A computational insight into binding modes of inhibitors XD29, XD35, and XD28 to bromodomain-containing protein 4 based on molecular dynamics simulations.
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P2860
Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Progress in the development an ...... in-acetyl-lysine interactions.
@en
type
label
Progress in the development an ...... in-acetyl-lysine interactions.
@en
prefLabel
Progress in the development an ...... in-acetyl-lysine interactions.
@en
P2093
P50
P356
P1476
Progress in the development an ...... in-acetyl-lysine interactions.
@en
P2093
Duncan A Hay
Laura E Jennings
Timothy P C Rooney
P304
P356
10.1021/JM300915B
P407
P577
2012-09-27T00:00:00Z