Catalytic in vivo protein knockdown by small-molecule PROTACs. - Test2 - elhamkhani - TriplyDB

Catalytic in vivo protein knockdown by small-molecule PROTACs.

Catalytic in vivo protein knockdown by small-molecule PROTACs.

http://www.wikidata.org/entity/Q34480735

about

Chemical genetics approaches for selective intervention in epigenetics Drugging the undruggables: exploring the ubiquitin system for drug development Targeting Protein-Protein Interactions in the HIF System Targeting protein function: the expanding toolkit for conditional disruption An Inducible System for Rapid Degradation of Specific Cellular Proteins Using Proteasome Adaptors Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition Discovering and understanding oncogenic gene fusions through data intensive computational approaches The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels.Selective degradation of splicing factor CAPERα by anticancer sulfonamides.Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.Induced protein degradation: an emerging drug discovery paradigm.Protein degradation: Prime time for PROTACs.In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).Structural basis of PROTAC cooperative recognition for selective protein degradation Chemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathway On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry.The chimeric ubiquitin ligase SH2-U-box inhibits the growth of imatinib-sensitive and resistant CML by targeting the native and T315I-mutant BCR-ABL PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer.New Modalities for Challenging Targets in Drug Discovery.Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds.BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.Privileged Electrophile Sensors: A Resource for Covalent Drug Development.Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression.Chemical Methods to Knock Down the Amyloid Proteins.Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.H3K36 methyltransferases as cancer drug targets: rationale and perspectives for inhibitor development Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.Targeted Protein Degradation by Small Molecules.Emerging Methods in Chemoproteomics with Relevance to Drug Discovery.Waste disposal-An attractive strategy for cancer therapy.Diverse ubiquitin linkages regulate RIP kinases-mediated inflammatory and cell death signaling.Targeted protein knockdown using small molecule degraders.Insecticide resistance and intracellular proteases.Targeted Protein Degradation: from Chemical Biology to Drug Discovery.Cullin-RING E3 Ubiquitin Ligases: Bridges to Destruction.Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras.Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands.pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase.Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.

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P2860

Catalytic in vivo protein knockdown by small-molecule PROTACs.

http://www.wikidata.org/entity/Q34480735

description

2015 nî lūn-bûn

@nan

2015 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի հունիսին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

name

Catalytic in vivo protein knockdown by small-molecule PROTACs.

@ast

Catalytic in vivo protein knockdown by small-molecule PROTACs.

@en

Catalytic in vivo protein knockdown by small-molecule PROTACs.

@nl

type

label

Catalytic in vivo protein knockdown by small-molecule PROTACs.

@ast

Catalytic in vivo protein knockdown by small-molecule PROTACs.

@en

Catalytic in vivo protein knockdown by small-molecule PROTACs.

@nl

prefLabel

Catalytic in vivo protein knockdown by small-molecule PROTACs.

@ast

Catalytic in vivo protein knockdown by small-molecule PROTACs.

@en

Catalytic in vivo protein knockdown by small-molecule PROTACs.

@nl

P1433

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P1433

Nature Chemical Biology

P1476

Catalytic in vivo protein knockdown by small-molecule PROTACs

@en

P2093

Afjal H Miah

http://www.w3.org/2001/XMLSchema#string

Alina Mares

http://www.w3.org/2001/XMLSchema#string

Bartholomew J Votta

http://www.w3.org/2001/XMLSchema#string

Carly Cox

http://www.w3.org/2001/XMLSchema#string

Daniel P Bondeson

http://www.w3.org/2001/XMLSchema#string

Deborah A Gordon

http://www.w3.org/2001/XMLSchema#string

Dennis L Buckley

http://www.w3.org/2001/XMLSchema#string

Eunhwa Ko

http://www.w3.org/2001/XMLSchema#string

Ian Churcher

http://www.w3.org/2001/XMLSchema#string

Ian E D Smith

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

Design, synthesis and selection of DNA-encoded small-molecule libraries

Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction

A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation

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P304

611-617

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scholarly article

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10.1038/NCHEMBIO.1858

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P433

8

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P478

11

http://www.w3.org/2001/XMLSchema#string

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Giovanna Bergamini

Linda N Casillas

Sebastien Campos

P577

2015-06-10T00:00:00Z

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26075522

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4629852

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