Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity. - Test2 - elhamkhani - TriplyDB

Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity.

Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity.

http://www.wikidata.org/entity/Q39978729

about

Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex Cellular mechanisms of γ-secretase substrate selection, processing and toxicity Toward the structure of presenilin/γ-secretase and presenilin homologs Complex regulation of γ-secretase: from obligatory to modulatory subunits Proteolytic processing of Alzheimer's β-amyloid precursor protein Trafficking and proteolytic processing of APP Allosteric regulation of rhomboid intramembrane proteolysis Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin The canonical Notch signaling pathway: unfolding the activation mechanism.Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.The secretases: enzymes with therapeutic potential in Alzheimer disease.Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production.Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's disease Structure of nicastrin unveils secrets of γ-secretase Activation and intrinsic gamma-secretase activity of presenilin 1.A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase.The dynamic conformational landscape of gamma-secretase.Amyloid and tau pathology of familial Alzheimer's disease APP/PS1 mouse model in a senescence phenotype background (SAMP8).The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's Disease Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain Toward structural elucidation of the gamma-secretase complex.Intramembrane proteolysis Intramembrane proteolysis by gamma-secretase.Presenilins: members of the gamma-secretase quartets, but part-time soloists too.Rip exposed: how ectodomain shedding regulates the proteolytic processing of transmembrane substrates.Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases.Intramembrane-cleaving proteases.Glu-333 of nicastrin directly participates in gamma-secretase activity.Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum.Therapeutic intervention for Alzheimer's disease with γ-secretase inhibitors: still a viable option?The many substrates of presenilin/γ-secretase.

P2860

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P2860

Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity.

http://www.wikidata.org/entity/Q39978729

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

@zh-hant

name

Glu

@nl

Glu(332) in the Nicastrin ecto ...... tion but not for its activity.

@en

type

label

Glu

@nl

Glu(332) in the Nicastrin ecto ...... tion but not for its activity.

@en

prefLabel

Glu

@nl

Glu(332) in the Nicastrin ecto ...... tion but not for its activity.

@en

P1433

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P1433

Journal of Biological Chemistry

P1476

Glu(332) in the Nicastrin ecto ...... tion but not for its activity.

@en

P2093

Alexandra Tolia

http://www.w3.org/2001/XMLSchema#string

Bart de Strooper

http://www.w3.org/2001/XMLSchema#string

Elke Maes

http://www.w3.org/2001/XMLSchema#string

Lucía Chávez-Gutiérrez

http://www.w3.org/2001/XMLSchema#string

Philip C Wong

http://www.w3.org/2001/XMLSchema#string

Tong Li

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P2860

Mechanism for multiple ligand recognition by the human transferrin receptor

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation.

Crystal structure of the ectodomain of human transferrin receptor

Streptomyces griseus aminopeptidase: X-ray crystallographic structure at 1.75 A resolution

Comparative protein modelling by satisfaction of spatial restraints

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

P304

20096-20105

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scholarly article

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10.1074/JBC.M803040200

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P407

P433

29

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P478

283

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2008-05-23T00:00:00Z

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5347050

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18502756

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