Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.
about
Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouseReassessment of the role of FKBP38 in the Rheb/mTORC1 pathwayUpregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemiaProtein kinases and phosphatases in the control of cell fateThe tuberous sclerosis complexMammalian target of rapamycin (mTOR): conducting the cellular signaling symphonyRapamycin and mTOR kinase inhibitorsThe TSC1-TSC2 complex: a molecular switchboard controlling cell growthmTOR signaling: at the crossroads of plasticity, memory and diseaseSystems biology: On the cell cycle and its switchesThe role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistanceRegulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane TargetingCutting through the complexities of mTOR for the treatment of strokeLeucine and mTORC1: a complex relationshipRegulation of mTORC1 by PI3K signalingShedding new light on neurodegenerative diseases through the mammalian target of rapamycinLifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegansMolecular Basis of the Acceleration of the GDP-GTP Exchange of Human Ras Homolog Enriched in Brain by Human Translationally Controlled Tumor ProteinA charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 bindingLarge FK506-Binding Proteins Shape the Pharmacology of RapamycinNoncanonical FK506-binding protein BDBT binds DBT to enhance its circadian function and forms foci at night.The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's diseaseHold me tight: Role of the heat shock protein family of chaperones in cardiac diseaseCadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell deathThe FKBP38 catalytic domain binds to Bcl-2 via a charge-sensitive loop.New structural aspects of FKBP38 activation.Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behaviorDirect control of mitochondrial function by mTOR.Targeting protein prenylation for cancer therapyRheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XLIntracellular parasitism with Toxoplasma gondii stimulates mammalian-target-of-rapamycin-dependent host cell growth despite impaired signalling to S6K1 and 4E-BP1.mTOR signaling in lymphangioleiomyomatosisInhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approachHepatitis C virus NS5A activates the mammalian target of rapamycin (mTOR) pathway, contributing to cell survival by disrupting the interaction between FK506-binding protein 38 (FKBP38) and mTORLovastatin induces VSMC differentiation through inhibition of Rheb and mTOR.The complexes of mammalian target of rapamycin.Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway.PTEN Tumor Suppressor Network in PI3K-Akt Pathway ControlBenzyl isothiocyanate causes FoxO1-mediated autophagic death in human breast cancer cells.Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment.
P2860
Q24310154-B5B1429D-5561-4753-94B4-46336AB3C423Q24311625-A0E29600-3CF7-4839-A212-67DA263C4EEDQ24317018-C7D50E65-8B10-4C19-BEFD-508F270118C1Q24604987-D4B9F83B-4403-4DB8-B456-50657A997E05Q24628011-F94CEAFF-15F9-4AD3-A995-C2C7D180F571Q24629514-3AA3B4DC-7CBE-491F-9516-56A873E4E393Q24644623-02D539C0-773E-43B8-A3A6-6F32B2B91125Q24645204-7F7B41F3-2FEB-4BC8-A7EB-DB33B1D7EB76Q24647655-D7051CF7-BC1E-4237-8D01-9CA516DE6DA4Q24650979-E27BE8F4-A741-4E49-AA25-C8D8C71DE02CQ26741046-A7B8222B-9C3B-4B51-8785-3E8C01F0C30BQ26783004-F5E47473-E9B3-493C-8077-CB83B981C86BQ26851291-E9CE392E-FBA2-4E20-9BCB-15247636E4F6Q26866321-72B1E754-303F-4024-91B9-711F17E0B052Q26995791-5FD54104-8FAD-4E73-A415-C389C625552DQ27015640-6E9D9F0E-3E2B-4207-9A48-F995A596D9B7Q27324080-C862588D-4E67-4C55-90FA-0DB9D44222DAQ27646385-0AEE1297-2EA1-47BF-8DB0-6DB691E93D88Q27659642-B506A215-9613-4BBF-AB9E-2ABE7987E1F4Q27676039-79DFF1E1-C5AD-4836-9189-EFDBEFD46BE8Q27680565-73C09A37-E2F7-4D78-B73E-18B22C0FD566Q28085108-42A5DA56-5888-48F2-A3D4-F7857168D108Q28296634-E2D0E202-E19C-4071-87E5-CF602E782932Q28577801-B074A6B3-97C6-47AD-BADF-52D5BE4C0B07Q30318118-5D3B7822-FF0E-4C3B-9E2E-1453EDDBF933Q30318601-7508F3A8-7F17-4D92-9973-9C7E38DCF2E8Q30485596-896265FD-2C6C-477E-8D5F-8DD205EF01A8Q33552261-AF750B50-CA9B-484E-B97F-694F3ECE17D7Q33679239-F6221FDF-F096-4377-A1C4-3126090CA610Q33726390-EF08CF2A-6908-4215-A1EF-D92127BCA601Q33894468-61B94BEF-E347-4699-8D3F-E3BFDB548E58Q33905253-57D89D8C-1812-435E-9559-6C8ADE82F8F1Q33925323-BD65A4E5-1DD8-4D18-995F-89BD5C695B9BQ33966987-6ED7E06D-6AD9-4934-B319-227826B7C5ACQ33995617-A485BECA-B7AF-4612-BEB9-E12E1734233FQ34116818-D3B34ABF-2C4F-4EC2-8426-6725DA0364CBQ34173253-87D88B14-5DC1-4D4E-91BE-09147AAB9B96Q34202681-ACD62A9E-E677-4C9C-B431-E9C9F434C83FQ34211672-F0186608-480B-45BC-8899-8C17EA97E2A2Q34260622-EAB11B78-1803-4682-A404-EB0D96B7B3E2
P2860
Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.
@en
type
label
Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.
@en
prefLabel
Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.
@en
P2093
P2860
P356
P1433
P1476
Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.
@en
P2093
Anling Liu
Dongzhu Ma
Qiming J Wang
Xiaochun Bai
Xiaoyun Shen
Yongjian Liu
P2860
P304
P356
10.1126/SCIENCE.1147379
P407
P577
2007-11-01T00:00:00Z