The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling.
about
A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcriptionLinking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)FRAXE-associated mental retardation protein (FMR2) is an RNA-binding protein with high affinity for G-quartet RNA forming structureCovalent histone modifications--miswritten, misinterpreted and mis-erased in human cancersAf9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortexRegulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalizationDOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cellsTargeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectivesSystematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer PathwaysChemical probes of histone lysine methyltransferasesCancer epigenetics drug discovery and development: the challenge of hitting the markLeukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.The AFF4 scaffold binds human P-TEFb adjacent to HIV TatPotent inhibition of DOT1L as treatment of MLL-fusion leukemiaEpigenome-based personalized medicine in human cancerMisguided transcriptional elongation causes mixed lineage leukemiaDegree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4New insights into behaviour using mouse ENU mutagenesisComparative genetic analysis: the utility of mouse genetic systems for studying human monogenic disease.Effects of RNAi-mediated knockdown of histone methyltransferases on the sex-specific mRNA expression of Imp in the silkworm Bombyx mori.Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in malesHsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression.AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.Protein network study of human AF4 reveals its central role in RNA Pol II-mediated transcription and in phosphorylation-dependent regulatory mechanisms.A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.Leukaemogenesis: more than mutant genesThe MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia.Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes.The MLL recombinome of acute leukemias in 2013.Development of a high-throughput screening-compatible assay for the discovery of inhibitors of the AF4-AF9 interaction using AlphaScreen technologyInhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancerHIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription.Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferationRequirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.
P2860
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P2860
The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The mixed-lineage leukemia fus ...... rdinated chromatin remodeling.
@en
type
label
The mixed-lineage leukemia fus ...... rdinated chromatin remodeling.
@en
prefLabel
The mixed-lineage leukemia fus ...... rdinated chromatin remodeling.
@en
P2093
P2860
P356
P1476
The mixed-lineage leukemia fus ...... rdinated chromatin remodeling.
@en
P2093
Emmanuelle Bitoun
Kay E Davies
Peter L Oliver
P2860
P304
P356
10.1093/HMG/DDL444
P577
2006-11-29T00:00:00Z