about
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomesTRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomesDVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocksRNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteinsCentrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinaseRNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteinsUbiquitin-activating enzyme UBA1 is required for cellular response to DNA damageHuman RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaksNonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosisMdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retentionHuman CtIP promotes DNA end resectionClaspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activationThe molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediatorDeregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregationSpatial organization of the mammalian genome surveillance machinery in response to DNA strand breaksRapid destruction of human Cdc25A in response to DNA damageA conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression.The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage.Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.ATR prohibits replication catastrophe by preventing global exhaustion of RPA.Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining.Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time.Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1Checking on DNA damage in S phase.Imaging of protein movement induced by chromosomal breakage: tiny 'local' lesions pose great 'global' challenges.Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage.Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks.More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance.53BP1 fosters fidelity of homology-directed DNA repair.The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling.The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases.LEDGF (p75) promotes DNA-end resection and homologous recombination.Profiling DNA damage response following mitotic perturbations.53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress.Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation.Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex.Deregulation of the RB pathway in human testicular germ cell tumours.Molecular biology. Shielding broken DNA for a quick fix.
P50
Q24292928-3774DC5E-D4DC-461B-8F34-739D92B6D8B9Q24295574-832162D6-BEB2-4010-86EA-1BF431A8B472Q24300382-CAC7706F-C55D-469F-96B3-84EE95296AD6Q24300411-B5CE98E9-38E4-4C8B-A6B7-2B3EBE5AB02CQ24301325-5CF2BDE3-8733-4C3C-837A-876DFBC0B41AQ24309287-6F1063F7-A8A4-46B1-A3E3-27852D264097Q24310132-7DDEDB80-76D6-4C63-97B3-0D1DBD2164AFQ24312250-4F2FD751-C5CC-4369-9E3F-37A69DCDDB0FQ24551182-E4C3C8B7-BFBE-437B-B39C-DA5B7D8E90F4Q24563397-E7A889F4-3823-4C27-91F1-1DA3E2F470BEQ24646062-74593087-FEDC-43B6-90A3-728178738AECQ24670580-D5F7D114-3A67-4979-893B-D2FA923CEE3AQ27676681-0F8AA53A-C670-4860-ADF5-5E60C283BD0FQ28207995-E8EDC91A-3411-4FEF-BC67-6924E205AEA7Q28235091-44E27F06-487D-47DC-90CC-18D5A3EFC332Q28611930-00243973-BCFA-43D4-AE2D-7252B31ABA5BQ33968253-77F589BB-14CF-4537-97A8-EA184B7FF6A5Q34110993-BDBCAC85-D71D-4545-874B-B95952C577FFQ34179079-D873C03A-6C2F-4B0F-AE49-5AD28066ADAAQ35051406-D67B6D06-3208-4C45-881F-C5FB17B14054Q35656738-1F0C0861-0440-43E0-894B-0529BE85819FQ35848480-56C5DABD-4A3F-435D-B60F-9BB1AB59345CQ35876274-C17D1EB2-6C2D-49B1-B4FA-E372D21BDA00Q35906070-A29CFB31-77CB-4C09-AE2C-2A601FC01AFBQ36179331-20A422CB-5514-4373-98DD-B60A666BF859Q36320732-462E23A6-70E1-4D63-9F92-A4A93D2818D6Q37130655-4C0C9431-2429-4AFF-81FE-C520FA5FC5E0Q37528453-5263A6DF-1369-4623-A805-D019304B05E2Q37942059-052A4106-8CFF-48AE-8357-742297421976Q38761656-FC36E13A-793B-437B-AF47-00E9FE889DF9Q39093521-F57D112B-06DE-430D-90B5-FA105101216AQ39160987-98A250DE-D358-4751-AF45-5F6320A1C1EDQ39318006-294BB6DD-1D4F-4018-BD9A-CA99E658CA48Q39510912-8CCC48C0-8A88-43E0-93C4-234787B59DE0Q39593027-9628AD78-18E7-491E-81FD-59AB2D5C6EA7Q40252252-FB806E97-F1FF-47BC-8A1C-FFB7887EE201Q40479936-1F1656EC-0B14-431E-BB90-0BFCA96C11E3Q40919505-72A5377E-04FC-4670-A7EC-28729EBE16FAQ42599532-760586A6-8D85-491C-BDBC-D88D23F57A55Q46488539-86CBEF07-6D55-45AA-9DD0-34E3C52DF78B
P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Claudia Lukas
@ast
Claudia Lukas
@da
Claudia Lukas
@de
Claudia Lukas
@en
Claudia Lukas
@es
Claudia Lukas
@fo
Claudia Lukas
@fr
Claudia Lukas
@is
Claudia Lukas
@kl
Claudia Lukas
@nb
type
label
Claudia Lukas
@ast
Claudia Lukas
@da
Claudia Lukas
@de
Claudia Lukas
@en
Claudia Lukas
@es
Claudia Lukas
@fo
Claudia Lukas
@fr
Claudia Lukas
@is
Claudia Lukas
@kl
Claudia Lukas
@nb
prefLabel
Claudia Lukas
@ast
Claudia Lukas
@da
Claudia Lukas
@de
Claudia Lukas
@en
Claudia Lukas
@es
Claudia Lukas
@fo
Claudia Lukas
@fr
Claudia Lukas
@is
Claudia Lukas
@kl
Claudia Lukas
@nb
P69
P106
P21
P31
P496
0000-0001-7169-6883