Functional organization of repeat addition processivity and DNA synthesis determinants in the human telomerase multimer.
about
Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTRStructural RNAs of known and unknown function identified in malaria parasites by comparative genomics and RNA analysisA human-Tetrahymena pseudoknot chimeric telomerase RNA reconstitutes a nonprocessive enzyme in vitro that is defective in telomere elongationIt all comes together at the ends: telomerase structure, function, and biogenesisEffect of pseudouridylation on the structure and activity of the catalytically essential P6.1 hairpin in human telomerase RNASaccharomyces cerevisiae telomerase subunit Est3p binds DNA and RNA and stimulates unwinding of RNA/DNA heteroduplexes.Telomerase Regulation from Beginning to the EndAn anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalizationProtein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomeraseRegulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domainComparative functional study of the viral telomerase RNA based on natural mutationsFunctional interaction between telomere protein TPP1 and telomeraseHuman telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivoExclusion of exon 2 is a common mRNA splice variant of primate telomerase reverse transcriptasesThe TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasisSoluble domains of telomerase reverse transcriptase identified by high-throughput screening.Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.Mutation in TERT separates processivity from anchor-site function.Human telomerase RNA template sequence is a determinant of telomere repeat extension rate.The telomerase-specific T motif is a restrictive determinant of repetitive reverse transcription by human telomeraseThe protein subunit of telomerase displays patterns of dynamic evolution and conservation across different metazoan taxa.Single-molecule fluorescence resonance energy transfer studies of the human telomerase RNA pseudoknot: temperature-/urea-dependent folding kinetics and thermodynamics.The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalizationA novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity.Telomerase can act as a template- and RNA-independent terminal transferase.Functional characterization of novel telomerase RNA (TERC) mutations in patients with diverse clinical and pathological presentations.A physical and functional constituent of telomerase anchor site.RNA-protein binding interface in the telomerase ribonucleoproteinRibonucleoprotein multimers and their functions.InTERTpreting telomerase structure and functionThe non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomeraseThe structure of an enzyme-activating fragment of human telomerase RNA.hnRNP A1 associates with telomere ends and stimulates telomerase activityIdentification of telomerase RNAs from filamentous fungi reveals conservation with vertebrates and yeasts.Direct involvement of the TEN domain at the active site of human telomerasePrediction of RNA binding sites in proteins from amino acid sequenceCloning and molecular characterization of telomerase reverse transcriptase (TERT) and telomere length analysis of Peromyscus leucopus.Characterization of physical and functional anchor site interactions in human telomerase.Modeling and structure function analysis of the putative anchor site of yeast telomerase.A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization.
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Functional organization of repeat addition processivity and DNA synthesis determinants in the human telomerase multimer.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Functional organization of rep ...... the human telomerase multimer.
@en
type
label
Functional organization of rep ...... the human telomerase multimer.
@en
prefLabel
Functional organization of rep ...... the human telomerase multimer.
@en
P2860
P1476
Functional organization of rep ...... the human telomerase multimer.
@en
P2093
Delphine T Marie-Egyptienne
Tara J Moriarty
P2860
P304
P356
10.1128/MCB.24.9.3720-3733.2004
P407
P577
2004-05-01T00:00:00Z