The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.
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SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation.Structural analysis and functional implications of the negative mTORC1 regulator REDD1mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4EMechanism of activation of protein kinase B by insulin and IGF-1Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioningSignaling by target of rapamycin proteins in cell growth controlMutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathwaysPhosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinasesA novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulinFunctional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translationIdentification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKASpatial regulation of the mTORC1 system in amino acids sensing pathwayPHLiPPing the switch on Akt and protein kinase C signalingDual requirement for a newly identified phosphorylation site in p70s6kThe TSC1-TSC2 complex: a molecular switchboard controlling cell growthRAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeletonInsulin utilizes the PI 3-kinase pathway to inhibit SP-A gene expression in lung epithelial cellsThe Cbk1p pathway is important for polarized cell growth and cell separation in Saccharomyces cerevisiaemTOR-dependent signalling in Alzheimer's diseaseGlucose exerts a permissive effect on the regulation of the initiation factor 4E binding protein 4E-BP1Suppression of survival signalling pathways by the phosphatase PHLPPImpaired overload-induced muscle growth is associated with diminished translational signalling in aged rat fast-twitch skeletal muscleLithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's diseaseMammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4ES6 phosphorylation-independent pathways regulate translation of 5'-terminal oligopyrimidine tract-containing mRNAs in differentiating hematopoietic cells.mTOR regulates phagosome and entotic vacuole fission.Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities.Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscleCirculating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression.Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A.Reduction of protein translation and activation of autophagy protect against PINK1 pathogenesis in Drosophila melanogaster.Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signalingProinflammatory stem cell signaling in cardiac ischemiaDisruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase.Absence of γ-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle.p70(S6K) controls selective mRNA translation during oocyte maturation and early embryogenesis in Xenopus laevis.p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex
P2860
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P2860
The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
The principal target of rapamy ...... conserved hydrophobic domain.
@en
type
label
The principal target of rapamy ...... conserved hydrophobic domain.
@en
prefLabel
The principal target of rapamy ...... conserved hydrophobic domain.
@en
P2093
P2860
P1433
P1476
The principal target of rapamy ...... a conserved hydrophobic domain
@en
P2093
P2860
P304
P356
10.1002/J.1460-2075.1995.TB00212.X
P407
P577
1995-11-01T00:00:00Z