Synthesis of natural-product-like molecules with over eighty distinct scaffolds
about
Motif mediated protein-protein interactions as drug targetsBinding of protein kinase inhibitors to synapsin I inferred from pair-wise binding site similarity measurementsHigh-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markersPhotochemical Approaches to Complex Chemotypes: Applications in Natural Product SynthesisA ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity.Towards vast libraries of scaffold-diverse, conformationally constrained oligomers.A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators.Exploration of Scaffolds from Natural Products with Antiplasmodial Activities, Currently Registered Antimalarial Drugs and Public Malarial Screen Data.Synthesis of unprecedented scaffold diversity.Small molecule macroarray construction via palladium-mediated carbon-carbon bond-forming reactions: highly efficient synthesis and screening of stilbene arrays.CYCLOADDITION REACTIONS OF AZIDE, FURAN, AND PYRROLE UNITS WITH BENZYNES GENERATED BY THE HEXADEHYDRO-DIELS-ALDER (HDDA) REACTIONComprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.Diversity through a branched reaction pathway: generation of multicyclic scaffolds and identification of antimigratory agents.Diverging DOS strategy using an allene-containing tryptophan scaffold and a library design that maximizes biologically relevant chemical space while minimizing the number of compounds.Creation and manipulation of common functional groups en route to a skeletally diverse chemical libraryTargeting protein-protein interactions for therapeutic intervention: a challenge for the future.Sequential transformations to access polycyclic chemotypes: asymmetric crotylation and metal carbenoid reactions.Branching cascades: a concise synthetic strategy targeting diverse and complex molecular frameworks.The rise, fall and reinvention of combinatorial chemistry.Towards the systematic exploration of chemical space.A biomimetic polyketide-inspired approach to small-molecule ligand discovery.Diversity-oriented synthesis: producing chemical tools for dissecting biology.1,2,4-trisubstituted cyclopentanes as platforms for diversity.Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.Is synthesis the main hurdle for the generation of diversity in compound libraries for screening?Emulating the logic of monoterpenoid alkaloid biogenesis to access a skeletally diverse chemical library.Electrophile induced branching cascade: a powerful approach to access various molecular scaffolds and their exploration as novel anti-mycobacterial agents.A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling.Discovery of novel FabF ligands inspired by platensimycin by integrating structure-based design with diversity-oriented synthetic accessibility.Direct comparison of linear and macrocyclic compound libraries as a source of protein ligandsTotal synthesis and biological evaluation of tyroscherin.A unified lead-oriented synthesis of over fifty molecular scaffolds.A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffoldsDe novo branching cascades for structural and functional diversity in small molecules.Medicinal chemistry for 2020Partially Saturated Bicyclic Heteroaromatics as an sp(3) -Enriched Fragment Collection.Heterocycle-heterocycle strategies: (2-nitrophenyl)isoxazole precursors to 4-aminoquinolines, 1H-indoles, and quinolin-4(1H)-ones.A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds.Opportunities for synthetic biology in antibiotics: expanding glycopeptide chemical diversity.
P2860
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P2860
Synthesis of natural-product-like molecules with over eighty distinct scaffolds
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Synthesis of natural-product-like molecules with over eighty distinct scaffolds
@en
Synthesis of natural-product-like molecules with over eighty distinct scaffolds
@en-gb
Synthesis of natural-product-like molecules with over eighty distinct scaffolds
@nl
type
label
Synthesis of natural-product-like molecules with over eighty distinct scaffolds
@en
Synthesis of natural-product-like molecules with over eighty distinct scaffolds
@en-gb
Synthesis of natural-product-like molecules with over eighty distinct scaffolds
@nl
prefLabel
Synthesis of natural-product-like molecules with over eighty distinct scaffolds
@en
Synthesis of natural-product-like molecules with over eighty distinct scaffolds
@en-gb
Synthesis of natural-product-like molecules with over eighty distinct scaffolds
@nl
P2860
P50
P356
P1476
Synthesis of natural-product-like molecules with over eighty distinct scaffolds
@en
P2093
Christopher Cordier
Stuart Leach
P2860
P304
P356
10.1002/ANIE.200804486
P407
P577
2009-01-01T00:00:00Z