Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product-based combinatorial libraries.
about
Discovery and resupply of pharmacologically active plant-derived natural products: A reviewPrivileged scaffolds for library design and drug discoveryCancer wars: natural products strike backChemical structure identification in metabolomics: computational modeling of experimental featuresInCHlib – interactive cluster heatmap for web applicationsRational methods for the selection of diverse screening compoundsUse of natural products as chemical library for drug discovery and network pharmacologyProtein structure similarity as guiding principle for combinatorial library design.Compound library development guided by protein structure similarity clustering and natural product structureCharting biologically relevant chemical space: a structural classification of natural products (SCONP)A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity.Novel chemical space exploration via natural productsExploration of Scaffolds from Natural Products with Antiplasmodial Activities, Currently Registered Antimalarial Drugs and Public Malarial Screen Data.Self-Organizing Maps for In Silico Screening and Data Visualization.Chemically engineered extracts as an alternative source of bioactive natural product-like compounds.Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries small molecule repository.Physiochemical property space distribution among human metabolites, drugs and toxins.Biology-oriented synthesis.A natural history of botanical therapeutics.Drug-likeness analysis of traditional Chinese medicines: 2. Characterization of scaffold architectures for drug-like compounds, non-drug-like compounds, and natural compounds from traditional Chinese medicinesDe novo branching cascades for structural and functional diversity in small molecules.SerpentinaDB: a database of plant-derived molecules of Rauvolfia serpentina.Classification of scaffold-hopping approachesPhytochemica: a platform to explore phytochemicals of medicinal plants.Disease-Specific Differentiation Between Drugs and Non-Drugs Using Principal Component Analysis of Their Molecular Descriptor Space.Chemical Diversity of Metabolites from Fungi, Cyanobacteria, and Plants Relative to FDA-Approved Anticancer Agents.An efficient system for heterologous expression of secondary metabolite genes in Aspergillus nidulans.Clustered distribution of natural product leads of drugs in the chemical space as influenced by the privileged target-sites.Chemical biology of histone acetyltransferase natural compounds modulators.Similar interactions of natural products with biosynthetic enzymes and therapeutic targets could explain why nature produces such a large proportion of existing drugs.Fragment informatics and computational fragment-based drug design: an overview and update.Perspectives on natural product epigenetic modulators in chemical biology and medicine.The structural biology of patellamide biosynthesisA systematic approach to prioritize drug targets using machine learning, a molecular descriptor-based classification model, and high-throughput screening of plant derived molecules: a case study in oral cancer.Synthesis of natural-product-like molecules with over eighty distinct scaffoldsComparative analysis of chemical similarity methods for modular natural products with a hypothetical structure enumeration algorithm.Hippeastrum reticulatum (Amaryllidaceae): Alkaloid Profiling, Biological Activities and Molecular Docking.Analysing and Navigating Natural Products Space for Generating Small, Diverse, But Representative Chemical Libraries.Harnessing the potential of natural products in drug discovery from a cheminformatics vantage point.Revealing the macromolecular targets of complex natural products.
P2860
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P2860
Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product-based combinatorial libraries.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Scaffold architecture and phar ...... based combinatorial libraries.
@ast
Scaffold architecture and phar ...... based combinatorial libraries.
@en
type
label
Scaffold architecture and phar ...... based combinatorial libraries.
@ast
Scaffold architecture and phar ...... based combinatorial libraries.
@en
prefLabel
Scaffold architecture and phar ...... based combinatorial libraries.
@ast
Scaffold architecture and phar ...... based combinatorial libraries.
@en
P356
P1476
Scaffold architecture and phar ...... based combinatorial libraries.
@en
P2093
P304
P356
10.1021/CC000097L
P577
2001-05-01T00:00:00Z