The NEDD8 pathway is essential for SCF(beta -TrCP)-mediated ubiquitination and processing of the NF-kappa B precursor p105.
about
Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copineStructural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugationE2-RING expansion of the NEDD8 cascade confers specificity to cullin modificationDiscovery of mammalian genes that participate in virus infectionInhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapyBuilding and remodelling Cullin-RING E3 ubiquitin ligasesMutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cellsThe bacterial fermentation product butyrate influences epithelial signaling via reactive oxygen species-mediated changes in cullin-1 neddylation.Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase.Protein neddylation: beyond cullin-RING ligases.Twists and turns in ubiquitin-like protein conjugation cascades.Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responsesGln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8.Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response.Adenosine and gastrointestinal inflammation.Glutamine attenuates inflammation and NF-kappaB activation via Cullin-1 deneddylation.Perturbation of neddylation-dependent NF-κB responses in the intestinal epithelium drives apoptosis and inhibits resolution of mucosal inflammation.Multifaceted roles of TRIM38 in innate immune and inflammatory responses.Subversion of innate immune responses by bacterial hindrance of NF-κB pathway.Targeting neddylation in cancer therapy.Tissue metabolism and the inflammatory bowel diseases.Ubiquitin-like protein MNSFβ regulates TLR-2-mediated signal transduction.CUL1, a component of E3 ubiquitin ligase, alters lymphocyte signal transduction with possible effect on rheumatoid arthritis.Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation.COP9 signalosome subunit 5 (CSN5/Jab1) regulates the development of the Drosophila immune system: effects on Cactus, Dorsal and hematopoiesis.
P2860
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P2860
The NEDD8 pathway is essential for SCF(beta -TrCP)-mediated ubiquitination and processing of the NF-kappa B precursor p105.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
The NEDD8 pathway is essential for SCF
@nl
The NEDD8 pathway is essential ...... the NF-kappa B precursor p105.
@en
type
label
The NEDD8 pathway is essential for SCF
@nl
The NEDD8 pathway is essential ...... the NF-kappa B precursor p105.
@en
prefLabel
The NEDD8 pathway is essential for SCF
@nl
The NEDD8 pathway is essential ...... the NF-kappa B precursor p105.
@en
P2860
P356
P1476
The NEDD8 pathway is essential ...... the NF-kappa B precursor p105.
@en
P2093
Kazuhiro Iwai
Ruthie E Amir
P2860
P304
23253-23259
P356
10.1074/JBC.M200967200
P407
P577
2002-04-12T00:00:00Z