A new level of conotoxin diversity, a non-native disulfide bond connectivity in alpha-conotoxin AuIB reduces structural definition but increases biological activity
about
Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activityStructure of α-conotoxin BuIA: influences of disulfide connectivity on structural dynamicsDistinct Disulfide Isomers of μ-Conotoxins KIIIA and KIIIB Block Voltage-Gated Sodium ChannelsCharacterization of a Novel α-Conotoxin TxID from Conus textile That Potently Blocks Rat α3β4 Nicotinic Acetylcholine ReceptorsClustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists.Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons.Conotoxins targeting nicotinic acetylcholine receptors: an overviewAlpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors.Oxidative folding and preparation of α-conotoxins for use in high-throughput structure-activity relationship studies.A novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily.Alanine scan of α-conotoxin RegIIA reveals a selective α3β4 nicotinic acetylcholine receptor antagonist.Physico-chemical characterization and synthesis of neuronally active alpha-conotoxins.Structure-activity relationships of alpha-conotoxins targeting neuronal nicotinic acetylcholine receptors.Bioinformatics-Aided VenomicsCloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif.Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails.Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors.Synthetic α-conotoxin mutants as probes for studying nicotinic acetylcholine receptors and in the development of novel drug leads.Structurally diverse μ-conotoxin PIIIA isomers block sodium channel NaV 1.4.Incorporation of post-translational modified amino acids as an approach to increase both chemical and biological diversity of conotoxins and conopeptides.Therapeutic conotoxins: a US patent literature survey.The role of defensive ecological interactions in the evolution of conotoxins.Enhancing the therapeutic potential of peptide toxins.Influence of disulfide connectivity on structure and bioactivity of α-conotoxin TxIA.αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype.Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives.Alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors.Molecular Engineering of Conus Peptides as Therapeutic Leads.Aqueous ionic liquids influence the disulfide bond isoform equilibrium in conotoxin AuIB: a consequence of the Hofmeister effect?Scrambling of Disulfide Bond Scaffolds in neurotoxin AuIB: A Molecular Dynamics Simulation Study.Temperature-dependent molecular dynamics study reveals an ionic liquid induced 310 - to α-helical switch in a neurotoxin.Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails.Role of CysI–CysIII Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors.A 3D structural model of RsXXVIA, an ω-conotoxin
P2860
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P2860
A new level of conotoxin diversity, a non-native disulfide bond connectivity in alpha-conotoxin AuIB reduces structural definition but increases biological activity
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
A new level of conotoxin diver ...... increases biological activity
@ast
A new level of conotoxin diver ...... increases biological activity
@en
A new level of conotoxin diver ...... increases biological activity
@nl
type
label
A new level of conotoxin diver ...... increases biological activity
@ast
A new level of conotoxin diver ...... increases biological activity
@en
A new level of conotoxin diver ...... increases biological activity
@nl
prefLabel
A new level of conotoxin diver ...... increases biological activity
@ast
A new level of conotoxin diver ...... increases biological activity
@en
A new level of conotoxin diver ...... increases biological activity
@nl
P2860
P50
P356
P1476
A new level of conotoxin diver ...... increases biological activity
@en
P2093
Paramjit S Bansal
Ron C Hogg
P2860
P304
48849-48857
P356
10.1074/JBC.M208842200
P407
P577
2002-10-09T00:00:00Z