Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.
about
Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADLSterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteinsDual functions of Insig proteins in cholesterol homeostasisInsig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienolsSchoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteinsPiperine Induces Hepatic Low-Density Lipoprotein Receptor Expression through Proteolytic Activation of Sterol Regulatory Element-Binding ProteinsA type 1 cholecystokinin receptor mutant that mimics the dysfunction observed for wild type receptor in a high cholesterol environment.Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductasePKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infection.Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis.Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.25-Hydroxycholesterol-3-sulfate attenuates inflammatory response via PPARγ signaling in human THP-1 macrophages.Impact of ursodeoxycholic acid on a CCK1R cholesterol-binding site may contribute to its positive effects in digestive function.Membrane cholesterol affects stimulus-activity coupling in type 1, but not type 2, CCK receptors: use of cell lines with elevated cholesterol.Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells.Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase.Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranesIntramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.Effects of atherogenic diet and atorvastatin treatment on gene expression profiles in the C57BL/6J mouse liver.Retrospective on Cholesterol Homeostasis: The Central Role of Scap.Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation.Xanthohumol Improves Diet-induced Obesity and Fatty Liver by Suppressing Sterol Regulatory Element-binding Protein (SREBP) Activation.A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products.Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation.Beneficial effects of β-sitosterol on type 1 cholecystokinin receptor dysfunction induced by elevated membrane cholesterol.Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation.Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner.microRNA-29 mediates a novel negative feedback loop to regulate SCAP/SREBP-1 and lipid metabolism.Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress.INSIG2 polymorphism and weight gain, dyslipidemia and serum adiponectin in Finnish patients with schizophrenia treated with clozapine.Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase.Cholesterol-induced conformational changes in the sterol-sensing domain of the Scap protein suggest feedback mechanism to control cholesterol synthesis.Manipulating Cholesterol Status Within Cells.Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs.Amplification of the gene for SCAP, coupled with Insig-1 deficiency, confers sterol resistance in mutant Chinese hamster ovary cells.
P2860
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P2860
Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Isolation of sterol-resistant ...... s in both Insig-1 and Insig-2.
@en
type
label
Isolation of sterol-resistant ...... s in both Insig-1 and Insig-2.
@en
prefLabel
Isolation of sterol-resistant ...... s in both Insig-1 and Insig-2.
@en
P2093
P2860
P356
P1476
Isolation of sterol-resistant ...... s in both Insig-1 and Insig-2.
@en
P2093
Navdar Sever
Peter C W Lee
Russell A Debose-Boyd
P2860
P304
25242-25249
P356
10.1074/JBC.M502989200
P407
P577
2005-05-02T00:00:00Z