Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes
about
Two-pore channels form homo- and heterodimersHax-1 identified as a two-pore channel (TPC)-binding proteinPhotoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin eggPhotoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cellsTPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+Two-pore channels function in calcium regulation in sea star oocytes and embryos.Two-pore channels at the intersection of endolysosomal membrane trafficReconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+High susceptibility to fatty liver disease in two-pore channel 2-deficient miceDomain assembly of NAADP-gated two-pore channelsExpression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cellsTPC: the NAADP discovery channel?Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomesAn NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signalsTwo-pore channels (TPCs): current controversiesConvergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinasesThe voltage-gated sodium channel TPC1 confers endolysosomal excitability.High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heartIdentification of epigenetic interactions between miRNA and DNA methylation associated with gene expression as potential prognostic markers in bladder cancerIdentification of a novel gene for diabetic traits in rats, mice, and humans.Function and dysfunction of two-pore channels.The human two-pore channel 1 is modulated by cytosolic and luminal calcium.The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentationMembrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation.Organelle-specific subunit interactions of the vertebrate two-pore channel family.Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channelsTwo-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.TRPML: transporters of metals in lysosomes essential for cell survival?Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion.Genetic Variants of TPCN2 Associated with Type 2 Diabetes Risk in the Chinese Population.Characterization of Two-Pore Channel 2 by Nuclear Membrane ElectrophysiologyTwo-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions.The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels.Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling.Physiological roles of NAADP-mediated Ca2+ signaling.Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease.Roles of cADPR and NAADP in pancreatic cells.Poring over two-pore channel pore mutants.From contraction to gene expression: nanojunctions of the sarco/endoplasmic reticulum deliver site- and function-specific calcium signals.
P2860
Q24337485-219CC35F-1933-4C78-9BE1-987C5E017DECQ24339389-F59BCD8C-4EA7-47F0-B925-53A736CCEAACQ24600390-06C58C1F-9C1A-4103-91DB-6EA3CB33CE5EQ24600457-EBC6C2F8-7089-4F2F-9550-E36184433FFEQ24621022-2240E574-68A1-4669-AB95-6913227C9A67Q27346606-ACC4F969-7BF5-4FAB-AB6C-C6C10587DDE1Q28085768-235A8EF8-437C-4F5C-947F-8B9E4C591C43Q28240502-30759D61-4F6F-4A29-B301-81816BED151FQ28246421-93E1DF56-6AA9-44E6-B5BD-F1F5D424A25DQ28250269-C095A53F-A54A-4613-9361-055472119708Q28260464-25106657-D673-49FF-8597-CB09E1134023Q28262391-A41D4405-CF22-4940-AB5E-EEF4DD6F47ADQ28264441-C89CD8E1-A0C7-4127-9FFA-C9A196C4D46FQ28276964-2C68F45A-CBF3-4140-A57A-0E0A3751DE08Q28294394-87338298-0067-46B6-AB81-EFE97FD5ECF5Q28302766-121DEDFD-FBA9-42A0-91C0-57C89F643124Q28307378-113E04D5-EAE1-4207-B8BA-72AB7897AFE1Q30810815-DFAB192B-AC42-4529-97A6-84D494E84378Q30835214-78A68BA5-F2AA-46CD-BDC0-DEB034DAE6E1Q33771011-92848C96-F2FF-4E66-9A97-707140C83FEBQ34242898-849A0964-1B97-473E-BB16-5B848904434FQ34483905-9EA4BB45-FC72-4DDB-BDBE-56BEFFDF6D52Q34552502-EA114DCA-6FF3-493B-9B1C-3AFE6C9FF5F2Q34583526-F9C2FD31-7F87-48D0-89AF-52DC823C6351Q34685254-C63852BF-5C54-413A-8DE5-6E43680E437CQ34958437-96902783-CA4A-40E1-906E-917E171428EEQ35067713-1329652B-2180-4C9C-9AFE-C55C2BEDAE01Q35082699-FBCACDED-0E1A-4513-9E61-60887D09A510Q35190170-46B709E3-E325-4534-A583-A94E842EDA94Q35771431-6107BEB0-CD8C-4DBD-A698-3B3FD0947208Q35937080-D0F684C6-098B-4DD5-88B0-1D12F2A6745CQ36536361-9411BCD6-6A00-42F0-A6FD-805139E6EAD4Q37613806-3F12C932-1E58-4A9A-9BAB-96402E44D0DAQ37870269-C980D4A1-05C6-45BC-B595-8378230F6756Q37904885-E6171A32-5DAB-42F7-978B-9C86646696E8Q37904890-A14DB13D-EC04-4FB9-B7AF-1312CD72D08CQ37944859-BB96D1D6-47B2-450A-BD89-1D0413E1659BQ38017031-6E7A4EFE-4F12-4B50-90E0-FD3D7C00F838Q38844674-258DB14A-8C72-4DB2-950D-03732518C97CQ38885377-B9A9842B-676B-4346-9133-9CE41683BF70
P2860
Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Characterization of two-pore c ...... currents in isolated lysosomes
@ast
Characterization of two-pore c ...... currents in isolated lysosomes
@en
Characterization of two-pore c ...... currents in isolated lysosomes
@nl
type
label
Characterization of two-pore c ...... currents in isolated lysosomes
@ast
Characterization of two-pore c ...... currents in isolated lysosomes
@en
Characterization of two-pore c ...... currents in isolated lysosomes
@nl
prefLabel
Characterization of two-pore c ...... currents in isolated lysosomes
@ast
Characterization of two-pore c ...... currents in isolated lysosomes
@en
Characterization of two-pore c ...... currents in isolated lysosomes
@nl
P2093
P2860
P3181
P356
P1476
Characterization of two-pore c ...... currents in isolated lysosomes
@en
P2093
Andrea Brüggemann
Christian A Wahl-Schott
Katrin Rötzer
Martin Biel
Michael Schieder
P2860
P304
P3181
P356
10.1074/JBC.C110.143123
P407
P577
2010-07-09T00:00:00Z