An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals
about
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADPDysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibitionTwo-pore channels form homo- and heterodimersHax-1 identified as a two-pore channel (TPC)-binding proteinPhotoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin eggPhotoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cellsMultifaceted roles of STIM proteinsTPC2 mediates new mechanisms of platelet dense granule membrane dynamics through regulation of Ca2+ release.Two-pore channels function in calcium regulation in sea star oocytes and embryos.Two-pore channels at the intersection of endolysosomal membrane trafficReconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+Domain assembly of NAADP-gated two-pore channelsExpression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cellsTPC: the NAADP discovery channel?Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomesBidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organellesTwo-pore channels (TPCs): current controversiesConvergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinasesLysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum.High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heartNicotinic Acid Adenine Dinucleotide 2'-Phosphate (NAADP) Binding Proteins in T-Lymphocytes.Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment.Function and dysfunction of two-pore channels.The human two-pore channel 1 is modulated by cytosolic and luminal calcium.The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentationMembrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation.Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channelsTwo-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomesNovel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening.Regulation of a proteinaceous elicitor-induced Ca2+ influx and production of phytoalexins by a putative voltage-gated cation channel, OsTPC1, in cultured rice cells.The intracellular Ca²⁺ channels of membrane traffic.Characterization of Two-Pore Channel 2 by Nuclear Membrane ElectrophysiologyIntracellular sphingosine releases calcium from lysosomes.The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion.Calcium pathway machinery at fertilization in echinodermsNicotinic acid adenine dinucleotide phosphate (NAADP) activates global and heterogeneous local Ca2+ signals from NAADP- and ryanodine receptor-gated Ca2+ stores in pulmonary arterial myocytesCrucial positively charged residues for ligand activation of the GPR35 receptor.Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions.
P2860
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P2860
An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals
@ast
An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals
@en
An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals
@nl
type
label
An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals
@ast
An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals
@en
An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals
@nl
prefLabel
An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals
@ast
An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals
@en
An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals
@nl
P2093
P2860
P50
P3181
P356
P1476
An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals
@en
P2093
Dev Churamani
Eugen Brailoiu
G Cristina Brailoiu
Robert Hooper
Taufiq Rahman
P2860
P304
38511-38516
P3181
P356
10.1074/JBC.M110.162073
P407
P577
2010-09-29T00:00:00Z