An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals - Wikidata - wikimedia - TriplyDB

An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals

An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals

http://www.wikidata.org/entity/Q28294394

about

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition Two-pore channels form homo- and heterodimers Hax-1 identified as a two-pore channel (TPC)-binding protein Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells Multifaceted roles of STIM proteins TPC2 mediates new mechanisms of platelet dense granule membrane dynamics through regulation of Ca2+ release.Two-pore channels function in calcium regulation in sea star oocytes and embryos.Two-pore channels at the intersection of endolysosomal membrane traffic Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+Domain assembly of NAADP-gated two-pore channels Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells TPC: the NAADP discovery channel?Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1 TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles Two-pore channels (TPCs): current controversies Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum.High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart Nicotinic Acid Adenine Dinucleotide 2'-Phosphate (NAADP) Binding Proteins in T-Lymphocytes.Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment.Function and dysfunction of two-pore channels.The human two-pore channel 1 is modulated by cytosolic and luminal calcium.The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation.Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening.Regulation of a proteinaceous elicitor-induced Ca2+ influx and production of phytoalexins by a putative voltage-gated cation channel, OsTPC1, in cultured rice cells.The intracellular Ca²⁺ channels of membrane traffic.Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology Intracellular sphingosine releases calcium from lysosomes.The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion.Calcium pathway machinery at fertilization in echinoderms Nicotinic acid adenine dinucleotide phosphate (NAADP) activates global and heterogeneous local Ca2+ signals from NAADP- and ryanodine receptor-gated Ca2+ stores in pulmonary arterial myocytes Crucial positively charged residues for ligand activation of the GPR35 receptor.Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions.

P2860

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P2860

An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals

http://www.wikidata.org/entity/Q28294394

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals

@ast

An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals

@en

An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals

@nl

type

label

An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals

@ast

An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals

@en

An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals

@nl

prefLabel

An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals

@ast

An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals

@en

An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals

@nl

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JBC.M110.162073

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Journal of Biological Chemistry

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An NAADP-gated two-pore channe ...... g from amplifying Ca2+ signals

@en

P2093

Dev Churamani

http://www.w3.org/2001/XMLSchema#string

Eugen Brailoiu

http://www.w3.org/2001/XMLSchema#string

G Cristina Brailoiu

http://www.w3.org/2001/XMLSchema#string

Robert Hooper

http://www.w3.org/2001/XMLSchema#string

Taufiq Rahman

http://www.w3.org/2001/XMLSchema#string

P2860

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

NAADP mobilizes calcium from acidic organelles through two-pore channels

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

Identification of a chemical probe for NAADP by virtual screening

Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells

NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs

An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles

Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling

Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes

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10.1074/JBC.M110.162073

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49

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285

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2992283

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