The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav
about
hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathwaysPositive and negative regulation of T-cell activation through kinases and phosphatasesRegulatory and signaling properties of the Vav familyDistinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor functionp95vav associates with the nuclear protein Ku-70SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signalingSignalling pathways induced by protease-activated receptors and integrins in T cellsVav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancerTwo Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk Association with VavDifferential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domainSignaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphataseMechanism and function of Vav1 localisation in TCR signalling.An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligandp95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cellsVav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activityPhosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation.Genes in the pX region of human T cell leukemia virus I influence Vav phosphorylation in T cells.Critical role of Ser-520 phosphorylation for membrane recruitment and activation of the ZAP-70 tyrosine kinase in T cells.ZAP-70 protein tyrosine kinase is constitutively targeted to the T cell cortex independently of its SH2 domainsRequirement for tyrosine residues 315 and 319 within zeta chain-associated protein 70 for T cell developmentT cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase.The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1.The Vav binding site (Y315) in ZAP-70 is critical for antigen receptor-mediated signal transduction.The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killingA functional T-cell receptor signaling pathway is required for p95vav activity.Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins.Vav1-mediated scaffolding interactions stabilize SLP-76 microclusters and contribute to antigen-dependent T cell responses.ZAP-70: an essential kinase in T-cell signalingTyrosine phosphorylation mediates both activation and downmodulation of the biological activity of VavVav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB.Characterization of the roles of SH2 domain-containing proteins in T-lymphocyte activation by using dominant negative SH2 domains.Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor functionT cell receptor (TCR) engagement in apoptosis-defective, but interleukin 2 (IL-2)-producing, T cells results in impaired ZAP70/CD3-zeta association.Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.Epitope-specific crosslinking of CD45 down-regulates membrane-associated tyrosine phosphatase activity and triggers early signalling events in human activated T cells.
P2860
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P2860
The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav
description
1994 nî lūn-bûn
@nan
1994 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav
@ast
The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav
@en
The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav
@nl
type
label
The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav
@ast
The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav
@en
The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav
@nl
prefLabel
The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav
@ast
The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav
@en
The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav
@nl
P2093
P1476
The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav
@en
P2093
P304
P407
P577
1994-12-23T00:00:00Z