DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity
about
alpha-Synuclein and neuronal cell deathPARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neuronsParkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavageThe role of oxidative stress in Parkinson's diseaseDJ-1 induces thioredoxin 1 expression through the Nrf2 pathwayRNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathwaysHuman DJ-1 and its homologs are novel glyoxalasesMitochondrial localization of DJ-1 leads to enhanced neuroprotectionDJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factorThe Tumorigenic Roles of the Cellular REDOX Regulatory SystemsStructural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1 † , ‡Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1Conservation of oxidative protein stabilization in an insect homologue of parkinsonism-associated protein DJ-1Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicityCross Talk between Two Antioxidant Systems, Thioredoxin and DJ-1: Consequences for CancerEvidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotectionDJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE)Mechanistic Nanotherapeutic Approach Based on siRNA-Mediated DJ-1 Protein Suppression for Platinum-Resistant Ovarian CancerBehavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase.DJ-1 knock-down impairs astrocyte mitochondrial function.Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice.DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70.Vascular endothelial growth factor-D modulates oxidant-antioxidant balance of human vascular endothelial cellsDJ-1, PINK1, and their effects on mitochondrial pathwaysDJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.Brain mitochondria from DJ-1 knockout mice show increased respiration-dependent hydrogen peroxide consumption.DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.Immunostaining of oxidized DJ-1 in human and mouse brainsNeuroproteomics as a promising tool in Parkinson's disease research.DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex.A plant DJ-1 homolog is essential for Arabidopsis thaliana chloroplast development.Effect of single amino acid substitution on oxidative modifications of the Parkinson's disease-related protein, DJ-1Oxidation of DJ-1 induced by 6-hydroxydopamine decreasing intracellular glutathione.Recent advances in the genetics of Parkinson's disease.Cinnamon treatment upregulates neuroprotective proteins Parkin and DJ-1 and protects dopaminergic neurons in a mouse model of Parkinson's disease.Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore openingRenal dopamine receptors, oxidative stress, and hypertension.DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.The genetics of Parkinson disease.
P2860
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P2860
DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity
description
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2005
@ast
im Dezember 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/12/30)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/12/30)
@nl
наукова стаття, опублікована в грудні 2005
@uk
name
DJ-1 up-regulates glutathione ...... A53T alpha-synuclein toxicity
@ast
DJ-1 up-regulates glutathione ...... A53T alpha-synuclein toxicity
@en
DJ-1 up-regulates glutathione ...... A53T alpha-synuclein toxicity
@nl
type
label
DJ-1 up-regulates glutathione ...... A53T alpha-synuclein toxicity
@ast
DJ-1 up-regulates glutathione ...... A53T alpha-synuclein toxicity
@en
DJ-1 up-regulates glutathione ...... A53T alpha-synuclein toxicity
@nl
prefLabel
DJ-1 up-regulates glutathione ...... A53T alpha-synuclein toxicity
@ast
DJ-1 up-regulates glutathione ...... A53T alpha-synuclein toxicity
@en
DJ-1 up-regulates glutathione ...... A53T alpha-synuclein toxicity
@nl
P3181
P356
P1476
DJ-1 up-regulates glutathione ...... A53T alpha-synuclein toxicity
@en
P2093
Curt R. Freed
Wenbo Zhou
P304
43150–43158
P3181
P356
10.1074/JBC.M507124200
P407
P577
2005-12-30T00:00:00Z