A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1
about
Microfluidics and coagulation biologyInhibition of cytoskeletal assembly by cytochalasin B prevents signaling through tyrosine phosphorylation and secretion triggered by collagen but not by thrombinGlycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagenMolecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3Signal transducer and activator of transcription 3 (STAT3) regulates collagen-induced platelet aggregation independently of its transcription factor activity.Rapid ubiquitination of Syk following GPVI activation in plateletsPlatelet 12-LOX is essential for FcγRIIa-mediated platelet activation.Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.Platelet-neutrophil interactions under thromboinflammatory conditionsSyncytiotrophoblast Extracellular Vesicles from Pre-Eclampsia Placentas Differentially Affect Platelet FunctionRegulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach.Phosphatidylinositol 3,4,5-trisphosphate regulates Ca(2+) entry via btk in platelets and megakaryocytes without increasing phospholipase C activity.Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice.Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor gamma chain complex on human platelets.The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice.Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation.Synthesis and biological applications of collagen-model triple-helical peptides.Extracellular chloride is required for efficient platelet aggregation.A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoidsThe heptapeptide LSARLAF mediates platelet activation through phospholipase Cgamma2 independently of glycoprotein IIb-IIIaDistinct roles of GPVI and integrin alpha(2)beta(1) in platelet shape change and aggregation induced by different collagens.Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activation.Convergence of alpha(v)beta(3) integrin- and macrophage colony stimulating factor-mediated signals on phospholipase Cgamma in prefusion osteoclastsEvidence for the involvement of p59fyn and p53/56lyn in collagen receptor signalling in human platelets.A collagen-related peptide regulates phospholipase Cgamma2 via phosphatidylinositol 3-kinase in human platelets.Glycoprotein VI/Fc receptor gamma chain-independent tyrosine phosphorylation and activation of murine platelets by collagen.Monomeric (glycine-proline-hydroxyproline)10 repeat sequence is a partial agonist of the platelet collagen receptor glycoprotein VI.Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells.A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter.Fyn/Lyn-mediated phosphorylation of FcR1 gamma
P2860
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P2860
A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1
description
1997 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1997
@ast
im Februar 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/02/15)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/02/15)
@nl
наукова стаття, опублікована в лютому 1997
@uk
مقالة علمية (نشرت في 15-2-1997)
@ar
name
A collagen-like peptide stimul ...... nt of the integrin alpha2beta1
@ast
A collagen-like peptide stimul ...... nt of the integrin alpha2beta1
@en
A collagen-like peptide stimul ...... nt of the integrin alpha2beta1
@nl
type
label
A collagen-like peptide stimul ...... nt of the integrin alpha2beta1
@ast
A collagen-like peptide stimul ...... nt of the integrin alpha2beta1
@en
A collagen-like peptide stimul ...... nt of the integrin alpha2beta1
@nl
prefLabel
A collagen-like peptide stimul ...... nt of the integrin alpha2beta1
@ast
A collagen-like peptide stimul ...... nt of the integrin alpha2beta1
@en
A collagen-like peptide stimul ...... nt of the integrin alpha2beta1
@nl
P2093
P1433
P1476
A collagen-like peptide stimul ...... nt of the integrin alpha2beta1
@en
P2093
J M Gibbins
L F Morton
M J Barnes
R W Farndale
P304
P407
P577
1997-02-01T00:00:00Z