p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.
about
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligaseCharacterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)Identification of differential proteins in nasopharyngeal carcinoma cells with p53 silence by proteome analysisRegulation of p53 function and stability by phosphorylationControl of cell cycle progression by c-Jun is p53 dependentThe human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sitesChk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53Activation of p53 in cervical carcinoma cells by small molecules.Regulation of Mutant p53 Protein ExpressionReactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancerSmall molecule compounds targeting the p53 pathway: are we finally making progress?An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivoInhibition of MDM2 by hsp90 contributes to mutant p53 stabilizationInactivation and inducible oncogenic mutation of p53 in gene targeted pigsPhosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damageFunctional interplay between MDM2, p63/p73 and mutant p53Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis.Overexpression of RBBP6, alone or combined with mutant TP53, is predictive of poor prognosis in colon cancer.KRAS and TP53 mutations in inflammatory bowel disease-associated colorectal cancer: a meta-analysis.Mdm2: the ups and downs.Molecular interaction map of the mammalian cell cycle control and DNA repair systems.Mutant p53: gain-of-function oncoproteins and wild-type p53 inactivators.The p53 pathway and apoptosis.Regulation of Mdm2-directed degradation by the C terminus of p53.The p53 tumor suppressor protein does not regulate expression of its own inhibitor, MDM2, except under conditions of stress.Regulation of p53 stability.Mutant TP53 posttranslational modifications: challenges and opportunities.DNA-binding and transactivation activities are essential for TAp63 protein degradation.Molecular pathogenesis of oral squamous carcinoma.Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stressNQO1 stabilizes p53 through a distinct pathway.Strategies for manipulating the p53 pathway in the treatment of human cancer.Epstein-Barr virus Latent Membrane Protein LMP1 reduces p53 protein levels independent of the PI3K-Akt pathway.Increased expression of prothymosin-α, independently or combined with TP53, correlates with poor prognosis in colorectal cancerThe role of mutant p53 in human cancer.From p63 to p53 across p73.Do VHL and HIF-1 mirror p53 and Mdm-2? Degradation-transactivation loops of oncoproteins and tumor suppressors.Pigmentation, Melanocyte Colonization, and p53 Status in Basal Cell CarcinomaP53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1
P2860
Q24295177-A1A024B0-008F-45C2-BE03-68A0E8845E0BQ24300162-B3A06751-4B8A-40C9-BF3E-C1EFEA4D8CA7Q24337782-F3FDEDC9-68C7-44CF-9E59-C7A7AB20D31AQ24554530-1B714F1B-F666-43B5-B69C-6C8CA386D2F8Q24607483-BA8509CF-695B-492E-A633-E5D74A662112Q24610054-B98524FA-7735-42DF-B88B-8F669DA4E6A1Q24610106-F4306A87-D475-4DF3-B019-A1AD8FC59932Q24644964-B64C9878-ECD8-4B9D-B1C3-765BBFE640C8Q26770579-83BDE663-BF8C-434C-BA8C-E09A37332632Q26800059-27D27F76-A06E-4697-869C-CACBAC5489B9Q27027835-056DCD61-F8A4-4887-8284-8F30C6DD417EQ28144965-F9F3743A-EEDD-4FFB-985C-2F6501A7A34CQ28212970-4ED5FC19-2CED-420B-9F06-7DCBFA1D9D1DQ28484241-95D1D443-DD12-4398-9013-8898F5204F32Q28609754-BD10A93F-056E-4F19-825B-08F80E961D2EQ28910323-144814C1-376F-409F-9A60-C958B4BB2368Q30886165-643B7C5B-2832-45D6-8B34-9379E1C72BE5Q31121056-ACEC81F8-FD4D-45CF-8B4C-A5EAC9D4E40DQ33591865-C2996644-E9B1-4423-9DCF-35E9D49D1303Q33594040-5E01291F-03EB-4AEE-B894-80D12BC52423Q33704559-44FDB8EF-D957-4A4E-885B-3D338D84B0A3Q33737277-BD0CFB8C-2BE3-4398-B0C6-3D3C005D44FDQ33738458-3D3D9FBC-279D-49DE-9E48-0255C00F1B44Q33779929-9424F7B6-2A62-4C19-A0AE-BB29253CD869Q33786947-DF42F348-87B8-4579-8192-E254A0C96468Q33807793-BD945C61-0CEA-4281-A97B-95B3AA7C297CQ33818479-C102B854-3E92-477F-8293-41A1B7797E8AQ33884223-C2DF4F36-8FE2-443D-81A0-F933015094B0Q33918555-CCC9A68E-DE60-4F2B-869D-DEE4746F84B9Q33958102-89D585C0-BD3E-4EA2-AB16-501671D3FBB0Q33997846-F21C89BC-D522-45B1-97D1-68FB9D47C9D0Q34016489-BBDB1C69-7E08-4111-BBF1-FE71F15D78ACQ34076012-824F424E-44D3-4E3C-867F-97B872848039Q34106993-9043C6F2-868D-4227-A82A-77EFBCCF8E8CQ34121399-12CC0460-A966-49C8-AD7B-78F68A13598DQ34153014-A11283FB-89C2-4D6C-AC17-AA4E082C55C9Q34164614-531AEAD9-2C4E-4E8D-8C3F-52EDBD828E96Q34226063-088F229F-E384-4DE4-A22D-19D76F26DD53Q34340573-A3913EC1-BBA7-4346-910D-2B320516806FQ34390794-5D275651-6671-410E-A9ED-2BA4D850BEDE
P2860
p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.
description
1997 nî lūn-bûn
@nan
1997 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
p53 protein stability in tumou ...... is dependent on Mdm2 binding.
@ast
p53 protein stability in tumou ...... is dependent on Mdm2 binding.
@en
type
label
p53 protein stability in tumou ...... is dependent on Mdm2 binding.
@ast
p53 protein stability in tumou ...... is dependent on Mdm2 binding.
@en
prefLabel
p53 protein stability in tumou ...... is dependent on Mdm2 binding.
@ast
p53 protein stability in tumou ...... is dependent on Mdm2 binding.
@en
P356
P1433
P1476
p53 protein stability in tumou ...... t is dependent on Mdm2 binding
@en
P2093
C A Midgley
P2888
P304
P356
10.1038/SJ.ONC.1201459
P407
P50
P577
1997-09-01T00:00:00Z
P5875
P6179
1014670955