Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis.
about
Out of balance: R-loops in human diseaseHuman senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent terminationThe RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substratesPosttranscriptional Regulation of Splicing Factor SRSF1 and Its Role in Cancer Cell BiologyBasic mechanisms in RNA polymerase I transcription of the ribosomal RNA genesBreaking bad: R-loops and genome integrityTranscriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrityMechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeR-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxiasRNase H2 roles in genome integrity revealed by unlinking its activitiesThe THO complex component Thp2 counteracts telomeric R-loops and telomere shorteningThe transcription elongation factor Spt5 influences transcription by RNA polymerase I positively and negatively.R-loop mediated transcription-associated recombination in trf4Δ mutants reveals new links between RNA surveillance and genome integrity.The Transcription Factor THO Promotes Transcription Initiation and Elongation by RNA Polymerase I.The SWI/SNF chromatin remodeling complex influences transcription by RNA polymerase I in Saccharomyces cerevisiaeThe nuclear RNA polymerase II surveillance system targets polymerase III transcripts.Redundancy in ribonucleotide excision repair: Competition, compensation, and cooperationRNA Exosome Regulates AID DNA Mutator Activity in the B Cell GenomeSMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control terminationCotranscriptional events in eukaryotic ribosome synthesisCcr4-not regulates RNA polymerase I transcription and couples nutrient signaling to the control of ribosomal RNA biogenesisGenome-destabilizing effects associated with top1 loss or accumulation of top1 cleavage complexes in yeastDeciphering Transcriptional Dynamics In Vivo by Counting Nascent RNA MoleculesRibonucleotides in DNA: Origins, repair and consequencesS1-DRIP-seq identifies high expression and polyA tracts as major contributors to R-loop formation.Distinguishing the roles of Topoisomerases I and II in relief of transcription-induced torsional stress in yeast rRNA genes.Mechanisms of genome instability induced by RNA-processing defects.The sub-nanomolar binding of DNA-RNA hybrids by the single-chain Fv fragment of antibody S9.6.A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expressionWhy eukaryotic cells use introns to enhance gene expression: splicing reduces transcription-associated mutagenesis by inhibiting topoisomerase I cutting activity.Regulation of BLM Nucleolar LocalizationMapping topoisomerase sites in mitochondrial DNA with a poisonous mitochondrial topoisomerase I (Top1mt).Synonymous but not the same: the causes and consequences of codon biasR-loop formation is a distinctive characteristic of unmethylated human CpG island promoters.Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chipGenome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondriaRibonuclease H2 in health and disease.Anchoring nascent RNA to the DNA template could interfere with transcriptionRNase H enables efficient repair of R-loop induced DNA damage.
P2860
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P2860
Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Loss of Topoisomerase I leads ...... uring ribosomal RNA synthesis.
@ast
Loss of Topoisomerase I leads ...... uring ribosomal RNA synthesis.
@en
type
label
Loss of Topoisomerase I leads ...... uring ribosomal RNA synthesis.
@ast
Loss of Topoisomerase I leads ...... uring ribosomal RNA synthesis.
@en
prefLabel
Loss of Topoisomerase I leads ...... uring ribosomal RNA synthesis.
@ast
Loss of Topoisomerase I leads ...... uring ribosomal RNA synthesis.
@en
P2860
P50
P356
P1433
P1476
Loss of Topoisomerase I leads ...... uring ribosomal RNA synthesis.
@en
P2093
Ann L Beyer
P2860
P304
P356
10.1101/GAD.573310
P577
2010-07-01T00:00:00Z