Matriptase activation, an early cellular response to acidosis.
about
Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1Crystal Structures of Matriptase in Complex with Its Inhibitor Hepatocyte Growth Factor Activator Inhibitor-1Human cancer cells retain modest levels of enzymatically active matriptase only in extracellular milieu following induction of zymogen activationMatriptase autoactivation is tightly regulated by the cellular chemical environmentsTargeting zymogen activation to control the matriptase-prostasin proteolytic cascade.Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiationDiversity of matriptase expression level and function in breast cancer.Increased matriptase zymogen activation in inflammatory skin disorders.Antithrombin regulates matriptase activity involved in plasmin generation, syndecan shedding, and HGF activation in keratinocytes.Intracellular and extracellular pH and Ca are bound to control mitosis in the early sea urchin embryo via ERK and MPF activities.Combinatorial optimization of cystine-knot peptides towards high-affinity inhibitors of human matriptase-1Detection of active matriptase using a biotinylated chloromethyl ketone peptideDifferential subcellular localization renders HAI-2 a matriptase inhibitor in breast cancer cells but not in mammary epithelial cellsMatriptase is inhibited by extravascular antithrombin in epithelial cells but not in most carcinoma cellsN-Glycan Branching Affects the Subcellular Distribution of and Inhibition of Matriptase by HAI-2/Placental BikuninMechanisms for the control of matriptase activity in the absence of sufficient HAI-1Natural Endogenous Human Matriptase and Prostasin Undergo Zymogen Activation via Independent Mechanisms in an Uncoupled Manner.Selective Inhibition of Prostasin in Human Enterocytes by the Integral Membrane Kunitz-Type Serine Protease Inhibitor HAI-2Reinforced Epithelial Barrier Integrity via Matriptase Induction with Sphingosine-1-Phosphate Did Not Result in Disturbances in Physiological Redox Status.Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis.Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas.Matriptase and prostasin are expressed in human skin in an inverse trend over the course of differentiation and are targeted to different regions of the plasma membrane.Matriptase expression and zymogen activation in human pilosebaceous unit.Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytesThe matriptase-prostasin proteolytic cascade in epithelial development and pathology.Impact of suppression of tumorigenicity 14 (ST14)/serine protease 14 (Prss14) expression analysis on the prognosis and management of estrogen receptor negative breast cancer.Regulation of pericellular proteolysis by hepatocyte growth factor activator inhibitor type 1 (HAI-1) in trophoblast cells.Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity.Roles of CUB and LDL receptor class A domain repeats of a transmembrane serine protease matriptase in its zymogen activation.Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin.Activated matriptase as a target to treat breast cancer with a drug conjugate.
P2860
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P2860
Matriptase activation, an early cellular response to acidosis.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Matriptase activation, an early cellular response to acidosis.
@ast
Matriptase activation, an early cellular response to acidosis.
@en
type
label
Matriptase activation, an early cellular response to acidosis.
@ast
Matriptase activation, an early cellular response to acidosis.
@en
prefLabel
Matriptase activation, an early cellular response to acidosis.
@ast
Matriptase activation, an early cellular response to acidosis.
@en
P2093
P2860
P356
P1476
Matriptase activation, an early cellular response to acidosis.
@en
P2093
Alexander P Vazzano
Chen-Yong Lin
Feng-Pai Chou
I-Chu Tseng
Joseph P Y Kao
Michael D Johnson
P2860
P304
P356
10.1074/JBC.M109.055640
P407
P577
2009-11-24T00:00:00Z