Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences. - Wikidata - wikimedia - TriplyDB

Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences.

Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences.

http://www.wikidata.org/entity/Q34081887

about

Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation.Purified human BRCA2 stimulates RAD51-mediated recombination CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51 Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer Homologous Recombination and Its Role in Carcinogenesis Gene conversion and deletion frequencies during double-strand break repair in human cells are controlled by the distance between direct repeats The role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapy Repair of strand breaks by homologous recombination Brca2 and Trp53 deficiency cooperate in the progression of mouse prostate tumourigenesis Fine tuning chemotherapy to match BRCA1 status Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice The Fanconi anaemia/BRCA pathway Mouse models of Fanconi anemia Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis Genetic steps of mammalian homologous repair with distinct mutagenic consequences Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks A genetic screen using the PiggyBac transposon in haploid cells identifies Parp1 as a mediator of olaparib toxicity DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks Double strand break repair functions of histone H2AX Homologs of breast cancer genes in plants RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair.Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions.Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint Human replication protein A-Rad52-single-stranded DNA complex: stoichiometry and evidence for strand transfer regulation by phosphorylation.Limiting the persistence of a chromosome break diminishes its mutagenic potential.The homologous recombination protein RAD51D protects the genome from large deletions Slip-sliding away: serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2 Rad51 inhibits translocation formation by non-conservative homologous recombination in Saccharomyces cerevisiae.Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance

P2860

Q22242910-3A25B31A-750D-45EF-86CA-E8A0B4723F15 Q24297031-FD6F2B54-D408-4C34-A9B4-3B36B300935E Q24299313-5EA3A304-81A3-4834-A796-D55CD6CEB7B9 Q24301487-B8F32403-F80F-4CDF-82E7-0B367FF518D6 Q24314901-335C9B87-D73F-4EC4-9C7D-CB49A08EAB67 Q24323065-E1C44933-CF63-4576-BA58-C3CFAD2A7749 Q24336963-6347A747-3C4F-483E-AFE9-A9691D26A527 Q24556631-0DDD2383-E768-4269-8258-4C4BB108F10D Q24563629-854F4A18-266D-42AC-B47C-B40FA3B49F3C Q24645423-3032F838-0E80-40A7-A084-8D5A6FB110EB Q24647338-B8D453BA-BBAD-4E9A-AE94-0E22575DDBF4 Q24793756-595AAEB6-6B14-4223-B85F-577E22F5EBA9 Q24803093-D9EA084F-2F89-4AF6-B26D-08FE46F3AB39 Q27010084-BB1D369F-6F7D-45A5-BD1F-EA665913F0B5 Q27012688-FB5BA0C4-73D3-4489-AB35-F5BADE8AE339 Q27347240-BBD8B797-7B64-4943-8169-B767EF5E33C7 Q27694529-2E32F16C-1AC4-4364-ACDB-6DED0B30337F Q28071541-1582B515-063B-4C67-8AA8-BBD2FEF1C9C6 Q28085364-B618375F-50DA-4710-A6A2-4F45E794A05C Q28180242-51DE361C-4FC1-4791-8789-008B80F5D79C Q28191400-92C2D584-A61B-4F49-AE2B-1D9A7EA286C3 Q28201371-59EDE4B7-EAA6-4ED7-A340-8F1EF515839F Q28244296-0374E67E-B2A7-4AAC-9BE2-F37E982CCFAB Q28274000-5C65BC1F-9AB0-4BC9-8BD7-9B02DF34C9CD Q28287955-EA06EC0B-0216-4D11-8349-0E72AE224259 Q28294399-E971A183-FD41-45B8-A5EE-F4815DB8CB32 Q28487036-E870A67E-8381-4FE3-A89F-24BCE64D201C Q28586983-ACC23C19-6ACC-4F75-8CFA-A36ED17D7BAA Q28609933-F9F97B0E-1A2F-4806-A9CF-8F888A472988 Q28661754-E0683571-491F-4CC0-8CC5-C0686A885264 Q28729894-57133E9A-D953-4B1C-BFEA-8D1DBB01B184 Q30780655-C0DFEA1C-669F-4C55-BCC7-2A773430C8EC Q33244989-E13C37EC-992E-4ADE-A3DD-9A82953AD977 Q33319284-8F3DFF35-A01D-4A2B-9749-90704447B894 Q33468536-E09FB466-F66E-4EB5-B589-22517B891314 Q33510904-880EEB34-B193-4C51-BB49-B18492AA4C22 Q33558155-39FB4E1A-CCC7-4E80-8E59-92667E06ABD9 Q33603068-263E4290-691A-484F-8BD2-9B9B92392DE9 Q33649800-0E76834E-90E1-4694-8407-34A4B2DA7139 Q33688407-1331A1E2-7BEB-42E1-9869-B215E5744BBE

P2860

Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences.

http://www.wikidata.org/entity/Q34081887

description

2001 nî lūn-bûn

@nan

2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2001年の論文

@ja

2001年論文

@yue

2001年論文

@zh-hant

2001年論文

@zh-hk

2001年論文

@zh-mo

2001年論文

@zh-tw

2001年论文

@wuu

name

Mutation in Brca2 stimulates e ...... ng between repeated sequences.

@ast

Mutation in Brca2 stimulates e ...... ng between repeated sequences.

@en

Mutation in Brca2 stimulates e ...... ng between repeated sequences.

@nl

type

label

Mutation in Brca2 stimulates e ...... ng between repeated sequences.

@ast

Mutation in Brca2 stimulates e ...... ng between repeated sequences.

@en

Mutation in Brca2 stimulates e ...... ng between repeated sequences.

@nl

prefLabel

Mutation in Brca2 stimulates e ...... ng between repeated sequences.

@ast

Mutation in Brca2 stimulates e ...... ng between repeated sequences.

@en

Mutation in Brca2 stimulates e ...... ng between repeated sequences.

@nl

P1433

Q34081887-39041B25-C9FA-4CF5-A88E-D31676382A5F

P1476

Q34081887-2E0DD51D-D12C-44A8-AEAC-AC8D3480EDC5

P2093

Q34081887-4F8A1221-45EC-4664-B24E-EE693AD3F89D

Q34081887-5C168BA7-6217-45E0-A734-BFF722EDB867

Q34081887-8769DB10-AB2D-4824-811D-81CD839EEE9B

Q34081887-C26C3E00-E841-433E-8115-95BD96FF8539

Q34081887-C3142317-78C3-4E8A-9BC9-AD42160B59AB

Q34081887-D0592055-DDBD-4421-AEB8-9BED8EE56A11

Q34081887-D8628D13-4800-459A-9180-6326F8AE80F9

Q34081887-F5B45FA3-9E17-4A1A-96AB-34E6D6DFCC10

Q34081887-FCC89576-7EDA-4DF8-8DF9-22CF5E7A2091

P2860

Q34081887-09CA63BB-5552-4ADD-8236-ADB285D1AB92

Q34081887-0EB8735B-A726-431C-87C7-FF2A49ADD94B

Q34081887-111288BE-DA26-4989-89FB-FED723E3AD63

Q34081887-11967278-4A6A-46A5-9B94-ED388BB11B1F

Q34081887-13019862-6705-416C-B19C-922D9CB3D5EA

Q34081887-16F58BD4-EE1E-472C-8462-AFB5538B6B1A

Q34081887-21B75E88-5060-4E40-8B5B-668237B034E5

Q34081887-30535026-4EEB-4CF0-AF02-EDE2700D9BE6

Q34081887-30877ADD-272C-498A-B766-6FFF4C497BC1

Q34081887-3278E7E5-2B0E-4D80-B99A-D0999DE0B4B5

P304

Q34081887-57297EE0-04CC-414E-AB2F-E6A6649E93F6

P31

Q34081887-40DC215B-6132-4B60-ACA8-9987168E20A9

P356

Q34081887-7CDDB234-EFD7-4E47-9C93-DA76146741FB

P407

Q34081887-1517C857-D58F-442C-8DD5-9EF47D7ED657

P433

Q34081887-533DB487-64A0-463F-BDF9-B84E0DCED6D9

P478

Q34081887-67857F96-AEC8-4871-A68F-20928A2FC28D

P577

Q34081887-E66265CD-3AAD-45E6-AA16-64E5B3557A76

P5875

Q34081887-29E4CAD0-40C8-44D3-B5F8-162518E96082

P698

Q34081887-8E62FAD5-279F-479E-B616-D4E95A4B1273

P932

Q34081887-F7274EBC-0C39-4556-A7AE-DAC2D7CF8A2F

P356

P1433

The EMBO Journal

P1476

Mutation in Brca2 stimulates e ...... ng between repeated sequences.

@en

P2093

Ashworth A

http://www.w3.org/2001/XMLSchema#string

Bertwistle D

http://www.w3.org/2001/XMLSchema#string

Gabriel A

http://www.w3.org/2001/XMLSchema#string

Griffin C

http://www.w3.org/2001/XMLSchema#string

Ross G

http://www.w3.org/2001/XMLSchema#string

Swift S

http://www.w3.org/2001/XMLSchema#string

Thacker J

http://www.w3.org/2001/XMLSchema#string

Tutt A

http://www.w3.org/2001/XMLSchema#string

Valentine J

http://www.w3.org/2001/XMLSchema#string

P2860

Initial sequencing and analysis of the human genome

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

The Rad51 paralog Rad51B promotes homologous recombinational repair

The BRCA2 gene product functionally interacts with p53 and RAD51

Genetic requirements for the single-strand annealing pathway of double-strand break repair in Saccharomyces cerevisiae

Genetic instabilities in human cancers

Genetic analysis of BRCA1 function in a defined tumor cell line

DNA double-strand breaks: signaling, repair and the cancer connection

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Association of BRCA1 with Rad51 in mitotic and meiotic cells

P304

4704-4716

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1093/EMBOJ/20.17.4704

http://www.w3.org/2001/XMLSchema#string

P407

P433

17

http://www.w3.org/2001/XMLSchema#string

P478

20

http://www.w3.org/2001/XMLSchema#string

P577

2001-09-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

11813194

http://www.w3.org/2001/XMLSchema#string

P698

11532935

http://www.w3.org/2001/XMLSchema#string

P932

125603

http://www.w3.org/2001/XMLSchema#string