ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import.
about
SOD1 misplacing and mitochondrial dysfunction in amyotrophic lateral sclerosis pathogenesisMitochondria in motor nerve terminals: function in health and in mutant superoxide dismutase 1 mouse models of familial ALSMitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target?Oxidative stress and mitochondrial damage: importance in non-SOD1 ALSHuntington's disease: underlying molecular mechanisms and emerging conceptsExploring new pathways of neurodegeneration in ALS: the role of mitochondria quality controlInhibition of mitochondrial protein import by mutant huntingtinBiogenesis of mitochondrial outer membrane proteins, problems and diseases.Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutantsElevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALSRole of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosisThe potential for transition metal-mediated neurodegeneration in amyotrophic lateral sclerosisMisfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset.Mechanisms, models and biomarkers in amyotrophic lateral sclerosisRepetitive nerve stimulation transiently opens the mitochondrial permeability transition pore in motor nerve terminals of symptomatic mutant SOD1 miceDelayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortexThe Broad Impact of TOM40 on Neurodegenerative Diseases in AgingComparison of dendritic calcium transients in juvenile wild type and SOD1(G93A) mouse lumbar motoneurons.Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1.Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition.Molecular signatures of amyotrophic lateral sclerosis disease progression in hind and forelimb muscles of an SOD1(G93A) mouse modelImmunoproteomic identification and characterization of Ni2+-regulated proteins implicates Ni2+ in the induction of monocyte cell death.OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instabilityMitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons.Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanismsALS-linked misfolded SOD1 species have divergent impacts on mitochondria.Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALSEndogenous macrophage migration inhibitory factor reduces the accumulation and toxicity of misfolded SOD1 in a mouse model of ALS.Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1.The Gdap1 knockout mouse mechanistically links redox control to Charcot-Marie-Tooth disease.Mitochondrial protein quality control in health and disease.SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments.Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis.SOD1 and mitochondria in ALS: a dangerous liaison.Neurodegeneration as a consequence of failed mitochondrial maintenance.Misfolded SOD1 and ALS: zeroing in on mitochondria.Amyotrophic lateral sclerosis: new genes, new models, and new mechanisms.Immunocytochemical localization of the translocase of the outer mitochondrial membrane (Tom20) in the human cochlea.Targeting mitochondrial metal dyshomeostasis for the treatment of neurodegeneration.
P2860
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P2860
ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
ALS-linked mutant superoxide d ...... and decreases protein import.
@ast
ALS-linked mutant superoxide d ...... and decreases protein import.
@en
ALS-linked mutant superoxide dismutase 1
@nl
type
label
ALS-linked mutant superoxide d ...... and decreases protein import.
@ast
ALS-linked mutant superoxide d ...... and decreases protein import.
@en
ALS-linked mutant superoxide dismutase 1
@nl
prefLabel
ALS-linked mutant superoxide d ...... and decreases protein import.
@ast
ALS-linked mutant superoxide d ...... and decreases protein import.
@en
ALS-linked mutant superoxide dismutase 1
@nl
P2093
P2860
P356
P1476
ALS-linked mutant superoxide d ...... n and decreases protein import
@en
P2093
Aaron O Bailey
Christine Vande Velde
John R Yates
Leah Winer
Meng-Qui Dong
Roderick A Capaldi
Seung-Joo Chun
P2860
P304
21146-21151
P356
10.1073/PNAS.1014862107
P407
P577
2010-11-15T00:00:00Z