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Retroviral DNA integration: reaction pathway and critical intermediates.

Retroviral DNA integration: reaction pathway and critical intermediates.

http://www.wikidata.org/entity/Q34500837

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Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2)Herpesvirus telomeric repeats facilitate genomic integration into host telomeres and mobilization of viral DNA during reactivation Retroviral intasome assembly and inhibition of DNA strand transfer Virological and cellular roles of the transcriptional coactivator LEDGF/p75 LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration The DNA damage response induced by infection with human cytomegalovirus and other viruses Foamy virus assembly with emphasis on pol encapsidation HIV-1 protease and reverse transcriptase control the architecture of their nucleocapsid partner Structural basis for functional tetramerization of lentiviral integrase Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration Functional and structural characterization of the integrase from the prototype foamy virus A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75 Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.The mechanism of retroviral integration from X-ray structures of its key intermediates Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site Assembly of prototype foamy virus strand transfer complexes on product DNA bypassing catalysis of integration A possible role for the asymmetric C-terminal domain dimer of Rous sarcoma virus integrase in viral DNA binding Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors 3′-Processing and strand transfer catalysed by retroviral integrasein crystallo Structural Basis of hAT Transposon End Recognition by Hermes, an Octameric DNA Transposase from Musca domestica Retroviral Integrase: Then and Now Engineered hyperactive integrase for concerted HIV-1 DNA integration Retroviral DNA Integration LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivity HIV virions as nanoscopic test tubes for probing oligomerization of the integrase enzyme.Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor Architecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linking Efficient and specific internal cleavage of a retroviral palindromic DNA sequence by tetrameric HIV-1 integrase.The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.Mass spectrometry-based footprinting of protein-protein interactions An unusual helix turn helix motif in the catalytic core of HIV-1 integrase binds viral DNA and LEDGF.An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule.RAG2's acidic hinge restricts repair-pathway choice and promotes genomic stability.Fidelity of target site duplication and sequence preference during integration of xenotropic murine leukemia virus-related virus.Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA.

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P2860

Retroviral DNA integration: reaction pathway and critical intermediates.

http://www.wikidata.org/entity/Q34500837

description

2006 nî lūn-bûn

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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի փետրվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Retroviral DNA integration: reaction pathway and critical intermediates.

@ast

Retroviral DNA integration: reaction pathway and critical intermediates.

@en

Retroviral DNA integration: reaction pathway and critical intermediates.

@nl

type

label

Retroviral DNA integration: reaction pathway and critical intermediates.

@ast

Retroviral DNA integration: reaction pathway and critical intermediates.

@en

Retroviral DNA integration: reaction pathway and critical intermediates.

@nl

prefLabel

Retroviral DNA integration: reaction pathway and critical intermediates.

@ast

Retroviral DNA integration: reaction pathway and critical intermediates.

@en

Retroviral DNA integration: reaction pathway and critical intermediates.

@nl

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SJ.EMBOJ.7601005

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The EMBO Journal

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Retroviral DNA integration: reaction pathway and critical intermediates.

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P2093

Michiyo Mizuuchi

http://www.w3.org/2001/XMLSchema#string

Min Li

http://www.w3.org/2001/XMLSchema#string

Robert Craigie

http://www.w3.org/2001/XMLSchema#string

Terrence R Burke

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P2860

HIV-1 integrase crosslinked oligomers are active in vitro

Protection of retroviral DNA from autointegration: involvement of a cellular factor

A new method for sequencing DNA

X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)--an initial glance of the viral DNA binding platform

Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase

Three-dimensional structure of the Tn5 synaptic complex transposition intermediate

Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding

Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein.

High-resolution structure of the catalytic domain of avian sarcoma virus integrase

Solution structure of the DNA binding domain of HIV-1 integrase

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1295-1304

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10.1038/SJ.EMBOJ.7601005

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6

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25

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2006-02-16T00:00:00Z

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