Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer. - Wikidata - wikimedia - TriplyDB

Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer.

Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer.

http://www.wikidata.org/entity/Q34502681

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STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis Heterotrimeric G proteins as emerging targets for network based therapy in cancer: End of a long futile campaign striking heads of a Hydra Activators of G protein signaling exhibit broad functionality and define a distinct core signaling triad Involvement of Girdin in the determination of cell polarity during cell migration Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway.Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation.Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors.Integrated Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) Quantitative Proteomic Analysis Identifies Galectin-1 as a Potential Biomarker for Predicting Sorafenib Resist Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy Dose- and time-dependent gene expression alterations in prostate and colon cancer cells after in vitro exposure to carbon ion and X-irradiation.Girdin regulates the migration and invasion of glioma cells via the PI3K-Akt signaling pathway.Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin Interleukin-17 promotes angiogenesis by stimulating VEGF production of cancer cells via the STAT3/GIV signaling pathway in non-small-cell lung cancer.Regulation of the G-protein regulatory-Gαi signaling complex by nonreceptor guanine nucleotide exchange factors.Evolutionary Conservation of a GPCR-Independent Mechanism of Trimeric G Protein Activation Girdin expression in cervical carcinoma and its role in the malignant properties of HeLa cells.GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells.Girdin (GIV) Expression as a Prognostic Marker of Recurrence in Mismatch Repair-Proficient Stage II Colon Cancer Clinical significance of Girdin expression detected by immunohistochemistry in non-small cell lung cancer.Carbon ion irradiation of the human prostate cancer cell line PC3: a whole genome microarray study.Discs large homolog 5 decreases formation and function of invadopodia in human hepatocellular carcinoma via Girdin and Tks5.GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis.GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression.Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation.Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration.Silencing the Girdin gene enhances radio-sensitivity of hepatocellular carcinoma via suppression of glycolytic metabolism.The Gαi-GIV binding interface is a druggable protein-protein interaction Prognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers.Girdin protein: A potential metastasis predictor associated with prognosis in lung cancer.Elevated expression of Girdin in the nucleus indicates worse prognosis for patients with estrogen receptor-positive breast cancer.Membrane Recruitment of the Non-receptor Protein GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Is Sufficient for Activating Heterotrimeric G Protein Signaling.Girdin/GIV regulates collective cancer cell migration by controlling cell adhesion and cytoskeletal organization

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P2860

Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer.

http://www.wikidata.org/entity/Q34502681

description

2010 nî lūn-bûn

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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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Expression of GIV/Girdin, a me ...... ient survival in colon cancer.

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Expression of GIV/Girdin, a me ...... ient survival in colon cancer.

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Expression of GIV/Girdin, a me ...... ient survival in colon cancer.

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Expression of GIV/Girdin, a me ...... ient survival in colon cancer.

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Expression of GIV/Girdin, a me ...... ient survival in colon cancer.

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Expression of GIV/Girdin, a me ...... ient survival in colon cancer.

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Expression of GIV/Girdin, a me ...... ient survival in colon cancer.

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Expression of GIV/Girdin, a me ...... ient survival in colon cancer.

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Barbara H Jung

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Betty Cabrera

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Jason Ear

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P2860

Involvement of chemokine receptors in breast cancer metastasis

Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles

A novel hook-related protein family and the characterization of hook-related protein 1

Akt/PKB regulates actin organization and cell motility via Girdin/APE

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer

Two G protein oncogenes in human endocrine tumors

Systematic review of microsatellite instability and colorectal cancer prognosis

A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

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