Many ways to telomere dysfunction: in vivo studies using mouse models.
about
Are Drosophila telomeres an exception or the rule?Human Ku70/80 associates physically with telomerase through interaction with hTERTMice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging.The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression.Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer developmentAblation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation.Increased p53 activity does not accelerate telomere-driven ageing.Assessment of telomere length and factors that contribute to its stability.Role of mammalian Rad54 in telomere length maintenance.Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis.Trials, tribulations, and trends in tumor modeling in mice.Telomeres, telomerase, and apoptosis.Epidemiology and molecular pathology at crossroads to establish causation: molecular mechanisms of malignant transformation.Deficient mismatch repair improves organismal fitness and survival of mice with dysfunctional telomeresGenetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae.Closed chromatin loops at the ends of chromosomes.Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcsH2AX regulates meiotic telomere clustering.Clinicopathological and molecular characteristics of gastric and colorectal carcinomas in the elderly.Premature aging in telomerase-deficient zebrafishTelomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations.Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice.Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition.Protection of internal (TTAGGG)n repeats in Chinese hamster cells by telomeric protein TRF1.Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment.Telomere dynamics in childhood leukemia and solid tumors: a follow-up study.Significance of cellular senescence in aging and cancer.Terc is dispensable for most of the short-term HPV16 oncogene-mediated phenotypes in mice.
P2860
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P2860
Many ways to telomere dysfunction: in vivo studies using mouse models.
description
2002 nî lūn-bûn
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2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Many ways to telomere dysfunction: in vivo studies using mouse models.
@ast
Many ways to telomere dysfunction: in vivo studies using mouse models.
@en
Many ways to telomere dysfunction: in vivo studies using mouse models.
@nl
type
label
Many ways to telomere dysfunction: in vivo studies using mouse models.
@ast
Many ways to telomere dysfunction: in vivo studies using mouse models.
@en
Many ways to telomere dysfunction: in vivo studies using mouse models.
@nl
prefLabel
Many ways to telomere dysfunction: in vivo studies using mouse models.
@ast
Many ways to telomere dysfunction: in vivo studies using mouse models.
@en
Many ways to telomere dysfunction: in vivo studies using mouse models.
@nl
P2860
P356
P1433
P1476
Many ways to telomere dysfunction: in vivo studies using mouse models.
@en
P2093
Fermín A Goytisolo
P2860
P2888
P304
P356
10.1038/SJ.ONC.1205085
P407
P577
2002-01-01T00:00:00Z
P5875
P6179
1031977888