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Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina

Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina

http://www.wikidata.org/entity/Q34556855

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Gene therapy of inherited retinal degenerations: prospects and challenges AAV-mediated gene therapy in mouse models of recessive retinal degeneration Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool Optogenetic Vision Restoration Using Rhodopsin for Enhanced Sensitivity.Review: the history and role of naturally occurring mouse models with Pde6b mutations Organizational motifs for ground squirrel cone bipolar cells Imaging the response of the retina to electrical stimulation with genetically encoded calcium indicators.Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells Limitations of encapsidation of recombinant self-complementary adeno-associated viral genomes in different serotype capsids and their quantitation Genetically targeted binary labeling of retinal neurons.Gene therapy with mitochondrial heat shock protein 70 suppresses visual loss and optic atrophy in experimental autoimmune encephalomyelitis.Gene augmentation for adRP mutations in RHO.Human hepatocyte growth factor receptor is a cellular coreceptor for adeno-associated virus serotype 3 Curing color blindness--mice and nonhuman primates Vector platforms for gene therapy of inherited retinopathies.Evaluation of lateral spread of transgene expression following subretinal AAV-mediated gene delivery in dogs Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors.Complex I subunit gene therapy with NDUFA6 ameliorates neurodegeneration in EAE High-efficiency transduction of liver cancer cells by recombinant adeno-associated virus serotype 3 vectors.Improving clinical efficacy of adeno associated vectors by rational capsid bioengineering.Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsia Intracellular transport of recombinant adeno-associated virus vectors.Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa.Controlling AAV Tropism in the Nervous System with Natural and Engineered Capsids.The AAV vector toolkit: poised at the clinical crossroads Gene therapy for retinitis pigmentosa caused by MFRP mutations: human phenotype and preliminary proof of concept.Gene therapy of inherited retinopathies: a long and successful road from viral vectors to patients.Retinal Gene Therapy: Current Progress and Future Prospects.Tyrosine-mutated AAV2-mediated shRNA silencing of PTEN promotes axon regeneration of adult optic nerve A novel bispecific molecule delivered by recombinant AAV2 suppresses ocular inflammation and choroidal neovascularization Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex.Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice.Impact of Heparan Sulfate Binding on Transduction of Retina by Recombinant Adeno-Associated Virus Vectors mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system.Safety and Biodistribution Evaluation in Cynomolgus Macaques of rAAV2tYF-PR1.7-hCNGB3, a Recombinant AAV Vector for Treatment of Achromatopsia AAV-mediated transduction and targeting of retinal bipolar cells with improved mGluR6 promoters in rodents and primates.Bioengineering of AAV2 capsid at specific serine, threonine, or lysine residues improves its transduction efficiency in vitro and in vivo.Targeted modifications in adeno-associated virus serotype 8 capsid improves its hepatic gene transfer efficiency in vivo

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P2860

Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina

http://www.wikidata.org/entity/Q34556855

description

2010 nî lūn-bûn

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2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina

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Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina

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Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina

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Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina

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Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina

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Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina

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Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina

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Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina

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Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina

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Molecular Therapy

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Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina

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Alfred S Lewin

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Andy W Neeley

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Antonette Bennett

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Arun Srivastava

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Astra Dinculescu

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Baozheng Li

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Giridhara R Jayandharan

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Hilda Petrs-Silva

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Ji-Jing Pang

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Lakshmanan Govindasamy

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P2860

A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells

Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions

The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy.

Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial

Safety and efficacy of gene transfer for Leber's congenital amaurosis

Effect of gene therapy on visual function in Leber's congenital amaurosis

Directed evolution of adeno-associated virus yields enhanced gene delivery vectors.

Adeno-associated virus serotypes: vector toolkit for human gene therapy.

Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential

Molecular evolution of adeno-associated virus for enhanced glial gene delivery.

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293-301

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10.1038/MT.2010.234

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2

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19

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Mavis Agbandje-McKenna

Astra Dinculescu

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2010-11-02T00:00:00Z

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47661698

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21045809

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3034844

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