Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina
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Gene therapy of inherited retinal degenerations: prospects and challengesAAV-mediated gene therapy in mouse models of recessive retinal degenerationRestoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic ToolOptogenetic Vision Restoration Using Rhodopsin for Enhanced Sensitivity.Review: the history and role of naturally occurring mouse models with Pde6b mutationsOrganizational motifs for ground squirrel cone bipolar cellsImaging the response of the retina to electrical stimulation with genetically encoded calcium indicators.Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cellsLimitations of encapsidation of recombinant self-complementary adeno-associated viral genomes in different serotype capsids and their quantitationGenetically targeted binary labeling of retinal neurons.Gene therapy with mitochondrial heat shock protein 70 suppresses visual loss and optic atrophy in experimental autoimmune encephalomyelitis.Gene augmentation for adRP mutations in RHO.Human hepatocyte growth factor receptor is a cellular coreceptor for adeno-associated virus serotype 3Curing color blindness--mice and nonhuman primatesVector platforms for gene therapy of inherited retinopathies.Evaluation of lateral spread of transgene expression following subretinal AAV-mediated gene delivery in dogsTargeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors.Complex I subunit gene therapy with NDUFA6 ameliorates neurodegeneration in EAEHigh-efficiency transduction of liver cancer cells by recombinant adeno-associated virus serotype 3 vectors.Improving clinical efficacy of adeno associated vectors by rational capsid bioengineering.Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and RatVitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsiaIntracellular transport of recombinant adeno-associated virus vectors.Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa.Controlling AAV Tropism in the Nervous System with Natural and Engineered Capsids.The AAV vector toolkit: poised at the clinical crossroadsGene therapy for retinitis pigmentosa caused by MFRP mutations: human phenotype and preliminary proof of concept.Gene therapy of inherited retinopathies: a long and successful road from viral vectors to patients.Retinal Gene Therapy: Current Progress and Future Prospects.Tyrosine-mutated AAV2-mediated shRNA silencing of PTEN promotes axon regeneration of adult optic nerveA novel bispecific molecule delivered by recombinant AAV2 suppresses ocular inflammation and choroidal neovascularizationHealthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex.Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice.Impact of Heparan Sulfate Binding on Transduction of Retina by Recombinant Adeno-Associated Virus VectorsmTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system.Safety and Biodistribution Evaluation in Cynomolgus Macaques of rAAV2tYF-PR1.7-hCNGB3, a Recombinant AAV Vector for Treatment of AchromatopsiaAAV-mediated transduction and targeting of retinal bipolar cells with improved mGluR6 promoters in rodents and primates.Bioengineering of AAV2 capsid at specific serine, threonine, or lysine residues improves its transduction efficiency in vitro and in vivo.Targeted modifications in adeno-associated virus serotype 8 capsid improves its hepatic gene transfer efficiency in vivo
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P2860
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina
@ast
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina
@en
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina
@nl
type
label
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina
@ast
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina
@en
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina
@nl
prefLabel
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina
@ast
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina
@en
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina
@nl
P2093
P2860
P356
P1433
P1476
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina
@en
P2093
Alfred S Lewin
Andy W Neeley
Antonette Bennett
Arun Srivastava
Astra Dinculescu
Baozheng Li
Giridhara R Jayandharan
Hilda Petrs-Silva
Ji-Jing Pang
Lakshmanan Govindasamy
P2860
P304
P356
10.1038/MT.2010.234
P577
2010-11-02T00:00:00Z