mTOR complex 2 in adipose tissue negatively controls whole-body growth - Wikidata - wikimedia - TriplyDB

mTOR complex 2 in adipose tissue negatively controls whole-body growth

mTOR complex 2 in adipose tissue negatively controls whole-body growth

http://www.wikidata.org/entity/Q34985009

about

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism An emerging role for TOR signaling in mammalian tissue and stem cell physiology Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy mTOR-dependent cell survival mechanisms Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond.Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex.Detection of QTL for traits related to adaptation to sub-optimal climatic conditions in chickens.Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis.Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice.Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta?Insulin growth factor binding protein 2 mediates the progression of lymphangioleiomyomatosis.mTORC2 in the center of cancer metabolic reprogramming The complexes of mammalian target of rapamycin.Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling Validation of reference genes for the relative quantification of gene expression in human epicardial adipose tissue.Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2 In vivo evidence for mTORC2-mediated actin cytoskeleton rearrangement in neurons Rapamycin-induced metabolic defects are reversible in both lean and obese mice Constitutive activation with overexpression of the mTORC2-phospholipase D1 pathway in uterine leiomyosarcoma and STUMP: morphoproteomic analysis with therapeutic implications.Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance.Mtor-Fanconi Anemia DNA Damage Repair Pathway in Cancer.Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors mTOR complex 2 signaling and functions Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats Autocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes.Alcohol-induced modulation of rictor and mTORC2 activity in C2C12 myoblasts.A novel adipose-specific gene deletion model demonstrates potential pitfalls of existing methods.mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue.Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism Hot topics in aging research: protein translation, 2009.Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2)Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.

P2860

Q24598427-34BD34C4-3276-4207-BA5B-E1FA9011911D Q24608263-053EBE0B-3491-46DE-848C-A2C97CB59F36 Q24629305-4EB2E6F3-510C-4F1C-80BE-BCAA6049F8D2 Q24632296-BA5B3498-2C92-4C52-858B-79B8172A1EFA Q26864688-BAAEEEFC-A505-4E0A-93A2-9615DCA6F7E8 Q27320013-8B048B60-6121-47A0-A802-982202AECEF3 Q28071388-6FA5FC92-697F-4062-92AC-2378D6FE6135 Q28270006-F89E6DAB-7A7D-455A-8941-2A35D1C4859C Q28276378-919DD135-FE36-4116-9374-2DAF896F3CCD Q28282926-D744F777-58B0-4734-90CB-48415B7CFFC2 Q30235555-9E37240A-E38D-4794-B548-B7394F138D5C Q30529898-118B2689-03C3-4748-9A2F-58366E90FB53 Q33587227-74CEE796-60AB-42B3-AFF1-E6956241E849 Q33600495-749120D3-D88E-4F22-8B35-FC21819FB625 Q33602622-77BAD507-114C-48C1-89B5-984721933358 Q33625989-12CD9340-81C4-4748-8C6E-29CEAA6DAAB5 Q33829595-C6997CA3-8972-403A-B04F-5D669DF798FC Q33831466-4B39C9C4-347B-43BD-8DF9-89F00885C314 Q34116818-8CC2A349-0011-42E6-A742-7AE53F98CA3D Q34170848-89FB862B-8806-4F71-864A-BC91830BB7C6 Q34236683-95D184E5-551F-4236-9AB7-FF39114BA71C Q34286779-A9DBD10B-D9F9-4BEB-96C9-4800B6025689 Q34362461-A40E8454-E60F-451C-9E65-9597785AA4A8 Q34461128-FA1AD89B-0FD2-4723-B592-9C8E633BEFD9 Q34566745-DD2F7B15-D5DA-4802-972F-4E0636E0CEBE Q34974398-0DC4ACE6-891A-4301-9E42-4B7DC7F044E9 Q35000084-377F2CFC-217D-4B36-A5FE-E0CC94D7F05D Q35356038-13F896FC-1740-44CD-A67A-BB4967761D15 Q35878519-44075A41-96E2-4B70-9813-F0DC1D770F96 Q36147346-734B5E7B-184B-4B4A-AACB-B4EC5A24E4A6 Q36386745-9271A98E-D7A3-44AF-BAA8-DC150F77F322 Q36415019-EC7A53B7-7A3D-4C13-ABC6-2410A1C55621 Q36533407-298BEABA-843A-4987-A936-AFBDD8065F75 Q36636089-4C9F4943-A7D8-47FC-A58F-0E9D0E993B0D Q36739499-739F4A27-5333-47ED-8222-FC720777A479 Q36772577-0C7D6D7C-371F-4E38-BE91-A8C76330FA83 Q36834656-0999D9FB-1110-47A1-A2B5-0B0EEEE1DB50 Q36905860-B5756F17-551A-4923-8BE9-8A9331088BF5 Q36939696-D2F65849-92B4-4B2C-9CD0-E6FD4A7671C5 Q37000488-76D0A04A-1F80-44F9-BB4D-3E417D155234

P2860

mTOR complex 2 in adipose tissue negatively controls whole-body growth

http://www.wikidata.org/entity/Q34985009

description

2009 nî lūn-bûn

@nan

2009 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

mTOR complex 2 in adipose tissue negatively controls whole-body growth

@ast

mTOR complex 2 in adipose tissue negatively controls whole-body growth

@en

mTOR complex 2 in adipose tissue negatively controls whole-body growth

@nl

type

label

mTOR complex 2 in adipose tissue negatively controls whole-body growth

@ast

mTOR complex 2 in adipose tissue negatively controls whole-body growth

@en

mTOR complex 2 in adipose tissue negatively controls whole-body growth

@nl

prefLabel

mTOR complex 2 in adipose tissue negatively controls whole-body growth

@ast

mTOR complex 2 in adipose tissue negatively controls whole-body growth

@en

mTOR complex 2 in adipose tissue negatively controls whole-body growth

@nl

P1433

Q34985009-487C03C0-0857-47D7-811B-1C8B6997D76D

P1476

Q34985009-4CE40D9B-175B-4A32-85B9-0C252030AB6E

P2093

Q34985009-125641EE-EF2D-48C6-A81A-17C4529ADC96

Q34985009-171DF81F-C9A6-47FC-82C5-0EFEAC187E46

Q34985009-301D04FA-4AB4-4D65-959B-1A7D7F95FA78

Q34985009-B64581AB-4106-43CD-A506-D7C758497378

P2860

Q34985009-0472D7B6-B8A4-43A4-B747-7E65A520AA9A

Q34985009-07B730CD-DCB1-42AC-82C5-CDADFA0762D7

Q34985009-0820745B-CB0B-49AC-9F07-946741F57E5F

Q34985009-0E2C70B1-551F-4581-B816-D775440ED7ED

Q34985009-1F3CF0A1-F910-4BF0-BB8C-702E5DD14947

Q34985009-239EFA0A-BC3D-48EC-A76B-12FE74484F6E

Q34985009-39B68CDC-15B2-4FD2-AA5C-A5ED19909C6F

Q34985009-3A3A651C-FEDD-49CB-899B-52BF771194E0

Q34985009-3D48B91E-678C-43C6-B81B-E59652627E78

Q34985009-48A7246A-18F4-44BA-9DAA-0B12425ED97C

P304

Q34985009-7636C35F-F617-43BA-92F3-9BC4A605D8E6

P31

Q34985009-1189AFC7-BB4E-4285-B6C4-4BB7CCAB8911

P356

Q34985009-04D9A0EC-1C0D-4C29-AC7B-4ABA522FC9AA

P407

Q34985009-F3A1A9D9-C238-4E52-B08E-800D8DEC70BC

P433

Q34985009-9968CEBC-FCEB-44DD-93B1-031E96D694F4

P478

Q34985009-3E47A6BF-7B32-4015-A218-E217F7439922

P50

Q34985009-F87C0F47-BE62-4885-BEBA-02B2FEDCDD6B

P577

Q34985009-AE5E845B-C9B8-4CD3-A56A-7D831A4B60E5

P5875

Q34985009-148BD6F5-0083-4AE9-B2F1-B2C550DA4AA3

P698

Q34985009-7AE214FC-405C-4C8D-B678-D30F90A657CD

P932

Q34985009-458F337E-21CC-4665-A833-C5430389382D

P356

PNAS.0811321106

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

mTOR complex 2 in adipose tissue negatively controls whole-body growth

@en

P2093

Markus A Rüegg

http://www.w3.org/2001/XMLSchema#string

Michael N Hall

http://www.w3.org/2001/XMLSchema#string

Nadine Cybulski

http://www.w3.org/2001/XMLSchema#string

Pazit Polak

http://www.w3.org/2001/XMLSchema#string

P2860

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1

P304

9902-9907

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.0811321106

http://www.w3.org/2001/XMLSchema#string

P407

P433

24

http://www.w3.org/2001/XMLSchema#string

P478

106

http://www.w3.org/2001/XMLSchema#string

P50

P577

2009-06-03T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

26268092

http://www.w3.org/2001/XMLSchema#string

P698

19497867

http://www.w3.org/2001/XMLSchema#string

P932

2700987

http://www.w3.org/2001/XMLSchema#string