mTOR complex 2 in adipose tissue negatively controls whole-body growth
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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevityFat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolismAn emerging role for TOR signaling in mammalian tissue and stem cell physiologyTargeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapymTOR-dependent cell survival mechanismsMechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growthJudicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and PerspectivesmTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTORThe Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and AgingBSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiationThe Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond.Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex.Detection of QTL for traits related to adaptation to sub-optimal climatic conditions in chickens.Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis.Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice.Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta?Insulin growth factor binding protein 2 mediates the progression of lymphangioleiomyomatosis.mTORC2 in the center of cancer metabolic reprogrammingThe complexes of mammalian target of rapamycin.Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signalingValidation of reference genes for the relative quantification of gene expression in human epicardial adipose tissue.Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2In vivo evidence for mTORC2-mediated actin cytoskeleton rearrangement in neuronsRapamycin-induced metabolic defects are reversible in both lean and obese miceConstitutive activation with overexpression of the mTORC2-phospholipase D1 pathway in uterine leiomyosarcoma and STUMP: morphoproteomic analysis with therapeutic implications.Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance.Mtor-Fanconi Anemia DNA Damage Repair Pathway in Cancer.Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumorsmTOR complex 2 signaling and functionsChronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in ratsAutocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes.Alcohol-induced modulation of rictor and mTORC2 activity in C2C12 myoblasts.A novel adipose-specific gene deletion model demonstrates potential pitfalls of existing methods.mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue.Recent Advances in Adipose mTOR Signaling and Function: Therapeutic ProspectsAblation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphologyAdipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolismHot topics in aging research: protein translation, 2009.Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2)Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.
P2860
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P2860
mTOR complex 2 in adipose tissue negatively controls whole-body growth
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
mTOR complex 2 in adipose tissue negatively controls whole-body growth
@ast
mTOR complex 2 in adipose tissue negatively controls whole-body growth
@en
mTOR complex 2 in adipose tissue negatively controls whole-body growth
@nl
type
label
mTOR complex 2 in adipose tissue negatively controls whole-body growth
@ast
mTOR complex 2 in adipose tissue negatively controls whole-body growth
@en
mTOR complex 2 in adipose tissue negatively controls whole-body growth
@nl
prefLabel
mTOR complex 2 in adipose tissue negatively controls whole-body growth
@ast
mTOR complex 2 in adipose tissue negatively controls whole-body growth
@en
mTOR complex 2 in adipose tissue negatively controls whole-body growth
@nl
P2093
P2860
P356
P1476
mTOR complex 2 in adipose tissue negatively controls whole-body growth
@en
P2093
Markus A Rüegg
Michael N Hall
Nadine Cybulski
Pazit Polak
P2860
P304
P356
10.1073/PNAS.0811321106
P407
P50
P577
2009-06-03T00:00:00Z