Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. - Wikidata - wikimedia - TriplyDB

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression.

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression.

http://www.wikidata.org/entity/Q35202114

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Down-regulation of Myc as a potential target for growth arrest induced by human polynucleotide phosphorylase (hPNPaseold-35) in human melanoma cells Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescence.Human polynucleotide phosphorylase selectively and preferentially degrades microRNA-221 in human melanoma cells The ornithine decarboxylase gene is essential for cell survival during early murine development Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression Inducible transgenics. New lessons on events governing the induction and commitment in mammary tumorigenesis.Cullin family proteins and tumorigenesis: genetic association and molecular mechanisms Promotion of S-phase entry and cell growth under serum starvation by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: association with inhibition of p27 accumulation N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis.Tumor suppressor ARF inhibits HER-2/neu-mediated oncogenic growth Myc/Max/Mad regulate the frequency but not the duration of productive cell cycles The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism Tbata modulates thymic stromal cell proliferation and thymus function Widespread genomic instability mediated by a pathway involving glycoprotein Ib alpha and Aurora B kinase.A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence.Regulation of the G1 to S transition by the ubiquitin pathway.The COP9 signalosome interacts with SCF UFO and participates in Arabidopsis flower development.MYC and the control of DNA replication.Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice.Repression of c-kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation The Max network gone mad.The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells.Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis.Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression p27Kip1 mediates addiction of ovarian cancer cells to MYCC (c-MYC) and their dependence on MYC paralogs.Scatter factor/hepatocyte growth factor stimulation of glioblastoma cell cycle progression through G(1) is c-Myc dependent and independent of p27 suppression, Cdk2 activation, or E2F1-dependent transcription.MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma.Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia.TGF-beta flips the Myc switch.Activated Src abrogates the Myc requirement for the G0/G1 transition but not for the G1/S transition.SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells.Loss of protooncogene c-Myc function impedes G1 phase progression both before and after the restriction point Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis.Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter.The INK4a/ARF locus and melanoma.Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis.

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P2860

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression.

http://www.wikidata.org/entity/Q35202114

description

2000 nî lūn-bûn

@nan

2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2000年の論文

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2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

Myc-enhanced expression of Cul ...... is and cell cycle progression.

@ast

Myc-enhanced expression of Cul ...... is and cell cycle progression.

@en

type

label

Myc-enhanced expression of Cul ...... is and cell cycle progression.

@ast

Myc-enhanced expression of Cul ...... is and cell cycle progression.

@en

prefLabel

Myc-enhanced expression of Cul ...... is and cell cycle progression.

@ast

Myc-enhanced expression of Cul ...... is and cell cycle progression.

@en

P1433

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P1433

Genes & Development

P1476

Myc-enhanced expression of Cul ...... is and cell cycle progression.

@en

P2093

F W Alt

http://www.w3.org/2001/XMLSchema#string

G David

http://www.w3.org/2001/XMLSchema#string

I M de Alboran

http://www.w3.org/2001/XMLSchema#string

M Ohh

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R A DePinho

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R C O'Hagan

http://www.w3.org/2001/XMLSchema#string

P2860

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis

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2185-2191

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10.1101/GAD.827200

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17

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14

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William G. Kaelin

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2000-09-01T00:00:00Z

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277431375

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10970882

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316894

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