Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations. - Wikidata - wikimedia - TriplyDB

Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.

Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.

http://www.wikidata.org/entity/Q35493964

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Roles and mechanisms of cellular senescence in regulation of tissue homeostasis NF-κB directly regulates Fas transcription to modulate Fas-mediated apoptosis and tumor suppression The sensitivity of diffuse large B-cell lymphoma cell lines to histone deacetylase inhibitor-induced apoptosis is modulated by BCL-2 family protein activity Non-cell-autonomous tumor suppression by p53.cGAS is essential for cellular senescence.A complex secretory program orchestrated by the inflammasome controls paracrine senescence.Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-activation Utilization of the Eμ-Myc mouse to model heterogeneity of therapeutic response.Nuclear factor-kappaB sensitizes to benzyl isothiocyanate-induced antiproliferation in p53-deficient colorectal cancer cells SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation.Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence.Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence.Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB.Lymphotoxin β receptor mediates caspase-dependent tumor cell apoptosis in vitro and tumor suppression in vivo despite induction of NF-κB activation.The NF-κB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma Lung tumor NF-κB signaling promotes T cell-mediated immune surveillance.NF-κB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression.Sprouty1 induces a senescence-associated secretory phenotype by regulating NFκB activity: implications for tumorigenesis.A novel cell-penetrating peptide derived from WT1 enhances p53 activity, induces cell senescence and displays antimelanoma activity in xeno- and syngeneic systems.Anti-cancer small molecule JP-8g exhibits potent in vivo anti-inflammatory activity.The diverse and complex roles of NF-κB subunits in cancer.Cellular senescence: a double-edged sword in the fight against cancer.Cellular senescence and its effector programs.CDK6-a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation.BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells.Noxa and cancer therapy: Tuning up the mitochondrial death machinery in response to chemotherapy.Sunitinib induces cellular senescence via p53/Dec1 activation in renal cell carcinoma cells.Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation.RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis The Two Faces of NF-κB Signaling in Cancer Development and Therapy.Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence.The Immortal Senescence.Senescence-associated reprogramming promotes cancer stemness.Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.hnRNP A1 antagonizes cellular senescence and senescence-associated secretory phenotype via regulation of SIRT1 mRNA stability.Detecting Markers of Therapy-Induced Senescence in Cancer Cells.

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Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.

http://www.wikidata.org/entity/Q35493964

description

2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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Opposing roles of NF-κB in ant ...... cross-species investigations.

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Opposing roles of NF-κB in ant ...... cross-species investigations.

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Opposing roles of NF-κB in ant ...... cross-species investigations.

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Bernd Dörken

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Claus Scheidereit

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Dido Lenze

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Georg Lenz

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Gregor Beuster

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Hua Jing

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Jan R Dörr

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Julia Kase

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Maja Milanovic

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Maurice Reimann

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P2860

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.

A predictive model for aggressive non-Hodgkin's lymphoma. The International Non-Hodgkin's Lymphoma Prognostic Factors Project

Chemokine signaling via the CXCR2 receptor reinforces senescence

Good cop, bad cop: the different faces of NF-kappaB

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10.1101/GAD.17620611

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Clemens A Schmitt

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