Phosphatidylinositol metabolism and polyoma-mediated transformation.
about
Should individual PI3 kinase isoforms be targeted in cancer?Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificityDirect association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 betaCloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85Phosphoinositides: tiny lipids with giant impact on cell regulationDirect association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinaseShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.A Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling.PKN binds and phosphorylates human papillomavirus E6 oncoprotein.Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptorsGeneration of a large library of point mutations in polyoma middle T antigen.Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity.Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.Serine 257 phosphorylation regulates association of polyomavirus middle T antigen with 14-3-3 proteinsThrombin-stimulated immunoprecipitation of phosphatidylinositol 3-kinase from human platelets.Natural biology of polyomavirus middle T antigen.Interleukin 1 stimulates phosphatidylinositol kinase activity in human fibroblastsPhosphatidylinositol kinase is activated in membranes derived from cells treated with epidermal growth factor.A protein kinase antigenically related to pp60v-src possibly involved in yeast cell cycle control: positive in vivo regulation by sterol.Reduction-oxidation (redox) state regulation of extracellular matrix metalloproteinases and tissue inhibitors in cardiac normal and transformed fibroblast cells.Transgenic expression of polyomavirus middle T antigen in the mouse prostate gives rise to carcinoma.Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens.Lessons in signaling and tumorigenesis from polyomavirus middle T antigen.A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site.Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen.Differentiation of myeloid cells is accompanied by increased levels of pp60c-src protein and kinase activity.Changes in frequency, morphology, and behavior of tumors induced in mice by a polyoma virus mutant with a specifically altered oncogene.Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A.Transformation and tumorigenic properties of a mutant polyomavirus containing a middle T antigen defective in Shc binding.Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle-T antigen of polyomavirusDissociation of inositol trisphosphate from diacylglycerol production in Rous sarcoma virus-transformed fibroblastsPRL-3 activates mTORC1 in Cancer Progression.A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity.Polyomavirus middle T-antigen NPTY mutants.Characterization of pp85, a target of oncogenes and growth factor receptorsThrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human plateletsStoichiometry of cellular and viral components in the polyomavirus middle-T antigen-tyrosine kinase complex.Polyomavirus transforms rat F111 and mouse NIH 3T3 cells by different mechanismsA completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity
P2860
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P2860
Phosphatidylinositol metabolism and polyoma-mediated transformation.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Phosphatidylinositol metabolism and polyoma-mediated transformation.
@ast
Phosphatidylinositol metabolism and polyoma-mediated transformation.
@en
type
label
Phosphatidylinositol metabolism and polyoma-mediated transformation.
@ast
Phosphatidylinositol metabolism and polyoma-mediated transformation.
@en
prefLabel
Phosphatidylinositol metabolism and polyoma-mediated transformation.
@ast
Phosphatidylinositol metabolism and polyoma-mediated transformation.
@en
P2093
P2860
P356
P1476
Phosphatidylinositol metabolism and polyoma-mediated transformation.
@en
P2093
B Schaffhausen
D R Kaplan
R L Garcea
T M Roberts
P2860
P304
P356
10.1073/PNAS.83.11.3624
P407
P577
1986-06-01T00:00:00Z